Results 121 to 130 of about 23,327,589 (260)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Time-varying coefficient models and measurement error [PDF]
, 2007 This thesis is concerned with presenting and developing modeling approaches which allow for a time-varying effect of covariates by using time-varying coefficients. The different approaches are compared in simulation studies.
Breitner, S., Breitner, Susanne
core +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Estimating Deterministically Time-Varying Variances in Regression Models [PDF]
The problem of structural change justifiably attracts considerable attention in econometrics. A number of different paradigms have been adopted ranging from structural breaks which are sudden and rare to time varying coefficient models which exhibit ...
George Kapetanios
core
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Periodic solutions for planar systems with time-varying delays
Electronic Journal of Differential Equations, 2005 This paper concerns delay differential systems that can be regarded as a model of two-neuron artificial neural network with delayed feedback. Some interesting results are obtained for the existence of a periodic solution for the system.
Chuangxia Huang +2 more
doaj
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
On the L2 stability of time-varying linear systems
, 1971 Two theorems giving sufficient conditions for a class of linear time-varying systems to be stable in the L2 sense are given. These theorems give better bounds than those in [4]
Vidyasagar, M.
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IET Control Theory & ApplicationsThe stabilization problem for uncertain discrete‐time singular Markovian jump systems (DSMJSs) with time‐varying delays is comprehensively covered in this paper.
Wenbin Chen, Fang Gao
doaj +1 more source