Results 91 to 100 of about 1,536,819 (313)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Spatially embedded dynamics and complexity
, 2010 To gain a deeper understanding of the impact of spatial embedding on the dynamics of complex systems we employ a measure of interaction complexity developed within neuroscience using the tools of statistical information theory. We apply this measure to a
Bullock, Seth, Buckley, Christopher L.
core +1 more source
Towards a Universal Measure of Complexity
, 2020 Recently, it has been argued that entropy can be a direct measure of complexity, where the smaller value of entropy indicates lower system complexity, while its larger value indicates higher system complexity. We dispute this view and propose a universal
Zbigniew R. Struzik +2 more
core +1 more source
Improved Time Complexities for Learning Boolean Networks
Entropy, 2013 Existing algorithms for learning Boolean networks (BNs) have time complexities of at least O(N · n0:7(k+1)), where n is the number of variables, N is the number of samples and k is the number of inputs in Boolean functions.
Chee Keong Kwoh, Yun Zheng
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
On the Subexponential Time Complexity of CSP
Proceedings of the AAAI Conference on Artificial Intelligence, 2013 A Constraint Satisfaction Problem (CSP) with n variables ranging over a domain of d values can be solved by brute-force in d^n steps (omitting a polynomial factor). With a more careful approach, this trivial upper bound can be improved for certain natural restrictions of the CSP.
Iyad Kanj, Stefan Szeider
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Linear time complexity de novo long read genome assembly with GoldRush. [PDF]
Nat Commun, 2023 Wong J +7 more
europepmc +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source