Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Efficient Algorithms for Subgraph Listing
Algorithms, 2014 Subgraph isomorphism is a fundamental problem in graph theory. In this paper we focus on listing subgraphs isomorphic to a given pattern graph. First, we look at the algorithm due to Chiba and Nishizeki for listing complete subgraphs of fixed size, and ...
Niklas Zechner, Andrzej Lingas
doaj +1 more source
Low-Complexity Acoustic Scene Classification Using Time Frequency Separable Convolution [PDF]
, 2022 Duc H. Phan, Douglas L. Jones
openalex +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Enhanced virtual release advancing algorithm for real-time task scheduling
Journal of Information and Telecommunication, 2018 In real-time task scheduling, response time and time complexity are two of important requirements that draw many attentions. Virtual release advancing (VRA) [Tanaka, K. (2015, June). Virtual release advancing for earlier deadlines.
D. Duy, K. Tanaka
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Time evolution of spread complexity in quenched Lipkin-Meshkov-Glick model [PDF]
, 2022 Mir Afrasiar +4 more
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Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
High-Precision and Low-Complexity Symbol Synchronization Algorithm Based on Dual-Threshold Amplitude Decision for Real-Time IMDD OFDM-PON [PDF]
, 2019 Junjie Peng +6 more
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Counterexamples expose gaps in the proof of time complexity for cover trees introduced in 2006 [PDF]
, 2022 Yury Elkin, Vitaliy Kurlin
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Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source