Results 141 to 150 of about 16,940,234 (305)

A quantum partial adiabatic evolution and its application to quantum search problem

Frontiers in Physics
This paper presents a framework for quantum partial adiabatic evolution and applies it to re-examine the well-known quantum search problem. We particularly focus on a detailed analysis of the algorithm’s success probability, which serves as a clear ...
Jie Sun, Jie Sun, Hui Zheng, Hui Zheng, Songfeng Lu   +4 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Reconstruction of Optical Coherence Tomography Images from Wavelength Space Using Deep Learning

Sensors
Conventional Fourier domain Optical Coherence Tomography (FD-OCT) systems depend on resampling into a wavenumber (k) domain to extract the depth profile.
Maryam Viqar, Erdem Sahin, Elena Stoykova, Violeta Madjarova   +3 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

A Study on Interaction Complexity and Time

CoRR
15 pages with 2 figures and 4 ...
Leonardo Germán Loza Bonora, Julián Grigera, Helmut Degen   +2 more
openaire   +3 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Why Philosophers Should Care About Computational Complexity [PDF]

, 2011
One might think that, once we know something is computable, how efficiently it can be computed is a practical question with little further philosophical importance. In this essay, I offer a detailed case that one would be wrong.
Scott Aaronson, Aaronson, Scott
core  

Reduced-Complexity Noncoherently Detected Differential Space-Time Shift Keying

Motivated by the recent development of Spatial Modulation (SM) and Differential Space-Time Shift Keying (DSTSK), we propose a reduced-complexity Conventional Differential Detector (CDD) as well as its reduced-complexity Multiple-Symbol Differential ...
Sugiura, Shinya, Ng, Soon, Xu, Chao, Hanzo, Lajos   +3 more
core   +1 more source