Results 81 to 90 of about 1,240,738 (311)

Input-Output Representation and Identifiability of Delay Parameters for Nonlinear Systems with Multiple Time-Delays

open access: yes, 2009
We have analyzed the identifiability of time-lag parameters in nonlinear delay systems using an algebraic framework. The identifiability is determined by the form of the system's input-output representation.
Wennberg, Bernt   +5 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimensional reduction of nonlinear time delay systems

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 2005
Whenever there is a time delay in a dynamical system, the study of stability becomes an infinite-dimensional problem. The centre manifold theorem, together with the classical Hopf bifurcation, is the most valuable approach for simplifying the infinite ...
M. S. Fofana
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Robust Sample-and-Hold Stabilization for Nonlinear Retarded Systems

open access: yes, 2016
In this paper we deal with the stabilization in the sample and hold sense of retarded systems affected by actuation disturbances and observation errors.
DI FERDINANDO, MARIO, PEPE, PIERDOMENICO
core   +1 more source

Positivity of Continuous-Time Descriptor Systems With Time Delays [PDF]

open access: yes, 2014
This technical note is concerned with positivity characteristic of continuous-time descriptor systems with time delays. First, a set of necessary and sufficient conditions is presented to check the property.
Yan, Xinggang   +3 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Analysis of delay fluctuationsin two-way time transfer earth stations

open access: yes, 2012
[[abstract]]The delay fluctuations in earth stations have become the main source of instability that degrades the accuracy of two-way satellite time and frequency transfer.
W. H. Tseng;H. T. Lin;P. C. Chang;S. Y. Lin;K. M. Feng
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

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