Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
On-scene time delays for epileptic seizures in emergencies during a social pandemic: A population-based study. [PDF]
Epilepsy Behav, 2023 Yamada H +8 more
europepmc +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
School start time delays and high school educational outcomes: Evidence from the START/LEARN study. [PDF]
J Adolesc, 2023 James SA +3 more
europepmc +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Neural Adaptive Funnel Dynamic Surface Control with Disturbance-Observer for the PMSM with Time Delays. [PDF]
Entropy (Basel), 2022 Li M, Li S, Zhang J, Wu F, Zhang T.
europepmc +1 more source
, 2018 AbstractDelays often occur between an input into a system and the output from that system. Delays complicate dynamics, create system instabilities, and reduce the information that systems can use to respond to the environment. Adjusting for delays often requires systems to predict future states based on past inputs.
openaire +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Asymptotic behavior of a predator-prey diffusion system with time delays
Electronic Journal of Differential Equations, 2005 In this paper, we study a class of reaction-diffusion systems with time delays, which models the dynamics of predator-prey species. The global asymptotic convergence is established by the upper-lower solutions and iteration method in terms of the ...
Yijie Meng, Yifu Wang
doaj
Evaluation of the Causes of Door-to-Balloon Time Delays in Patients with ST-Elevation Myocardial Infarction at Tehran Heart Center. [PDF]
J Tehran Heart Cent, 2023 Emami M +5 more
europepmc +1 more source