Results 101 to 110 of about 1,406,233 (296)

TIME DELAYS AND THE UNDERWRITING CYCLE [PDF]

We shall consider the concept of time delays and the extent to which this is a common feature in many general insurance systems. We shall then present an example of a model of an insurance system with delays that helps to explain the phenomenon of ...
Carmen Pricină, Ovidiu Solomon
core  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Time-Delayed Quantum Feedback Control [PDF]

Physical Review Letters, 2015
A theory of time-delayed coherent quantum feedback is developed. More specifically, we consider a quantum system coupled to a bosonic reservoir creating a unidirectional feedback loop. It is shown that the dynamics can be mapped onto a fictitious series of cascaded quantum systems, where the system is driven by past versions of itself.
openaire   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Analysis and control of issues that delay pharmaceutical projects

Business: Theory and Practice, 2015
Every project will have certain objectives and service levels to be achieved. The success of a project depends on several dimensions like time, cost/budget, quality, etc.
Nasina Jigeesh, Nallam Sai Nandeswara Rao   +1 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Dispersive Time-Delay Dynamical Systems

Physical Review Letters, 2017
We present a theoretical approach to model the dynamics of a dispersive nonlinear system using a set of delay differential equations with distributed delay term. We illustrate the use of this approach by considering a frequency swept laser comprimising a semiconductor optical amplifier (SOA), a tunable bandpass filter and a long dispersive fiber delay ...
Huyet, Guillaume, Slepneva, Svetlana, Pimenov, Alexander, Vladimirov, Andrei G.   +3 more
openaire   +4 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Mathematical model on influence of past experiences on present activities of human brain

Computational and Mathematical Biophysics
This article explores how emotional feelings linked to stored memories of past experiences influence the present activity of the human brain. To analyse this, a mathematical model is considered describing the dynamics in a two-layered network in which ...
Rao P. Raja Sekhara, Ratnam K. Venkata, Shirisha G.   +2 more
doaj   +1 more source

Reliability Modeling of Systems with Undetected Degradation Considering Time Delays, Self-Repair, and Random Operating Environments

Mathematics
In some settings, systems may not fail completely but instead undergo performance degradation, leading to reduced efficiency. A significant concern arises when a system transitions into a degraded state without immediate detection, with the degradation ...
Hoang Pham
doaj   +1 more source