Results 61 to 70 of about 873,223 (267)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Review of Soil Creep Characteristics and Advances in Modelling Research

open access: yesBuildings
Creep is recognised to be an important physical property of soils, exerting a profound influence on the stability of structures. In order to gain a comprehensive understanding of the advancements and focal points in soil creep research, the relevant ...
Yanchao Liu   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

TIME-DEPENDENT PRINCIPLES OF INVARIANCE [PDF]

open access: yesProceedings of the National Academy of Sciences, 1958
Author(s): Preisendorfer, Rudolph W | Abstract: SIO Reference 57-51. In this note, we exhibit the formulation of the requisite statements of the four tijne-dependent principles of invariance and show that they are sufficient todorivethe functional relations governing the tine-dependent R and T functions and their corresponding integral operator.
openaire   +4 more sources

Examining the time dependence of DAMA’s modulation amplitude

open access: yesEuropean Physical Journal C: Particles and Fields, 2018
If dark matter is composed of weakly interacting particles, Earth’s orbital motion may induce a small annual variation in the rate at which these particles interact in a terrestrial detector. The DAMA collaboration has identified at a $$9.3\sigma $$ 9.3σ
Chris Kelso   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Time‐Dependent Circular Billiard [PDF]

open access: yesMathematical Problems in Engineering, 2009
We investigate a time‐dependent circular billiard with a two‐frequency driving function and derive a new simplified form for the map, which is a symplectic nontwist map. Stability boundaries and reconnection thresholds are derived for fixed points and period‐two vortex pairs.
openaire   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Time dependence of object wave amplitude at four-wave mixing with allowance for resonant and thermal nonlinearities

open access: yesФизика волновых процессов и радиотехнические системы, 2013
The analytical expression connecting the time dependence of spatial spectrum of object wave with the time dependence of spatial spectrum of signal wave has been obtained for degenerate four-wave radiation converter on resonant and thermal nonlinearities.
A.A. Akimov   +2 more
doaj  

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