Results 191 to 200 of about 34,299,178 (233)

Identification of MEF2A, MEF2C, and MEF2D interactomes in basal and Fsk‐stimulated mouse MA‐10 Leydig cells

Andrology, EarlyView.
Abstract Background Myocyte enhancer factor 2 transcription factors regulate essential transcriptional programs in various cell types. The activity of myocyte enhancer factor 2 factors is modulated through interactions with cofactors, chromatin remodelers, and other regulatory proteins, which are dependent on cell context and physiological state.
Karine de Mattos, Marie‐Pier Scott‐Boyer, Arnaud Droit, Robert S. Viger, Jacques J. Tremblay   +4 more
wiley   +1 more source

Underexplored Catalysts as General Structures: Application of Machine Learning Techniques for Reaction-Specific Datasets. [PDF]

Angew Chem Int Ed Engl
Li J, Betinol IO, Lai J, Juyo S, Reid JP.   +4 more
europepmc   +1 more source

Detection of zoonotic bacteria in wild Australian freshwater turtles

Australian Veterinary Journal, EarlyView.
Freshwater turtles are long‐lived, abundant components of Australian aquatic ecosystems, yet little is known about the diversity and prevalence of zoonotic bacteria they may carry. In this study, we conducted one of the most comprehensive surveys to date of zoonotic microorganisms associated with wild Australian freshwater turtles.
TF Scheelings, TTH Van, RJ Moore, LF Skerratt   +3 more
wiley   +1 more source

A Qualitative Study Exploring the Acceptability of Taking Part in a Large Multicentre RCT of Medication for Anxiety in Autistic Adults (the STRATA Trial). [PDF]

Autism
Realpe AX, Norris JE, Lorenc A, Cotton L, Morgan Z, Sadik A, Rai D, Mills N, Strata Collaboration Group.   +8 more
europepmc   +1 more source

Selective modulation of NaV channel gating counteracts aberrant hyperexcitability and rescues motor function and survival in a model of spinal muscular atrophy

British Journal of Pharmacology, EarlyView.
Background and Purpose Spinal muscular atrophy (SMA) is a motor neuron disease caused by SMN1 gene loss, leading to reduced survival motor neuron (SMN) protein and progressive motor neuron degeneration. Although SMN‐restoring therapies improve outcomes, residual disease burden and non‐curative efficacy underscore the need for complementary treatments ...
Fernanda C. Cardoso, Jessica A. I. Muller, Yougang Zhang, Jean Giacomotto   +3 more
wiley   +1 more source

Deprotonation suppressing via competitive proton transfer control for efficient perovskite solar cells. [PDF]

Nat Commun
Dong H, Qu J, Wang S, Chen D, Chai W, Wang W, Zhu W, Xi H, Zhou L, Zhang J, Huang P, Hao Y, Zhang C.   +12 more
europepmc   +1 more source

A Biweekly GLP‐1R Agonist Designed With Drug‐Free Intervals for Enhanced Efficacy, Receptor Homeostasis and Gastrointestinal Tolerability

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim To develop a next‐generation, longer‐acting, more‐clinical‐benefits agonist to achieve sustained efficacy with improved tolerability. Methods CT130 was designed from semaglutide. Binding affinity was validated via molecular dynamics and cellular assays.
Wei Ding, Qing Liu, Qiong Luo, Xiaojun Yao, Xingxing Fan   +4 more
wiley   +1 more source

Effect of dynamic cerebral autoregulation of cerebral blood flow regulation during cold pressor test. [PDF]

Physiol Rep
Ogoh S, Ito K, Kaji M, Kunimatsu N, Tatsuta K, Shibasaki M.   +5 more
europepmc   +1 more source

Phosphomimetic statherin‐derived peptide protects against intrinsic enamel erosion independently of sodium trimetaphosphate

European Journal of Oral Sciences, EarlyView.
Abstract This in vitro study evaluated the effect of a phosphomimetic statherin‐derived peptide (DDSt15), alone or combined with sodium trimetaphosphate (TMP), on the protection against initial enamel erosion. A total of 102 bovine enamel samples (4 × 4 mm2) were prepared and randomly allocated into six groups (n = 17): deionized water (negative ...
Carolina Ruis Ferrari, Hannah Zomignan Barros, Julia Pereira Bicalho, João Victor Frazão Câmara, Monique Malta Francese, Lethycia Almeida Santos, Juliano Pelim Pessan, Naiara Maia Pereira, Reinaldo Marchetto, Marília Afonso Rabelo Buzalaf   +9 more
wiley   +1 more source

Maternal diet and fatty acids in human milk: results of the MELK study. [PDF]

Eur J Nutr
Petersohn I, Zock PL, Knipping K, Brouwer-Brolsma EM, Feskens EJM.   +4 more
europepmc   +1 more source