Results 131 to 140 of about 1,454,719 (294)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Vehicle Localization Using Doppler Shift and Time of Arrival Measurements in a Tunnel Environment. [PDF]

Sensors (Basel), 2022
Halili R, BniLam N, Yusuf M, Tanghe E, Joseph W, Weyn M, Berkvens R.   +6 more
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Deep Learning Approaches for Robust Time of Arrival Estimation in Acoustic Emission Monitoring. [PDF]

Sensors (Basel), 2022
Zonzini F, Bogomolov D, Dhamija T, Testoni N, De Marchi L, Marzani A.   +5 more
europepmc   +1 more source

Valuation of uncertainty in travel time and arrival time - some findings from a choice experiment [PDF]

We are developing a dynamic modeling framework in which we can evaluate the effects of different road pricing measures on individual choice behavior as well as on a network level.
Dirk Van Amelsfort, Michiel Bliemer
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The Life Satisfaction of Immigrants in Canada: Does Time Since Arrival Matter more than Income? [PDF]

J Int Migr Integr, 2022
Monteiro L, Haan M.
europepmc   +1 more source

TOASTER: Times-Of-Arrival Tracker

, 2020
TOASTER is a pulse times-of-arrival (TOA) tracker. It stores reduced/folded observations, meta data, templates, parfiles, TOAs, and timefiles in an organized manner using an SQL database. TOASTER also provides a full-featured python toolkit for reliably interacting with the data and database, and provides scripts that, for example, list and summarize ...
Lazarus, P., Bassa, C., Desvignes, G., Hessels, J., Verbiest, J., Karuppusamy, R.   +5 more
openaire   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Evaluation of 5G Positioning Based on Uplink SRS and Downlink PRS Under LOS and NLOS Environments

Applied Sciences
The evolution of 5G technology has led to significant advancements in high-accuracy positioning. However, the actual performance of 5G signals for user equipment (UE) positioning has not been thoroughly examined, especially under varying propagation ...
Syed Shahid Shah, Chao Sun, Dongkai Yang, Muhammad Wisal, Yingzhe He, Bai Lu, Ying Xu   +6 more
doaj   +1 more source