Results 171 to 180 of about 339,040 (317)
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Time-of-arrival detection for time-resolved scanning transmission X-ray microscopy imaging. [PDF]
J Synchrotron Radiat, 2020 Finizio S, Mayr S, Raabe J.
europepmc +1 more source
THE CHALLENGES OF TIME-BASED ARRIVAL MANAGEMENT
, 2010 DLR’s arrival manager 4D-CARMA (4 Dimensional Co-operative ARrival MAnager) supports time-based arrival management.
Helmke, Hartmut
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
A Novel Method for Asynchronous Time-of-Arrival-Based Source Localization: Algorithms, Performance and Complexity. [PDF]
Sensors (Basel), 2020 Chen Y, Yao Z, Peng Z.
europepmc +1 more source
Clips: a capacity and lead time integrated procedure for scheduling. [PDF]
We propose a general procedure to address real life job shop scheduling problems. The shop typically produces a variety of products, each with its own arrival stream, its own route through the shop and a given customer due date.
Lambrecht, Marc +2 more
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Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Staffing service centers under arrival-rate uncertainty
, 2012 textWe consider the problem of staffing large-scale service centers with multiple customer classes and agent types operating under quality-of-service (QoS) constraints.
Zan, Jing, 1983-
core