Results 121 to 130 of about 21,021,490 (340)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
How Time Preferences Differ: Evidence from 45 Countries [PDF]
We present results from the first large-scale international survey on time discounting, conducted in 45 countries. Cross-country variation cannot simply be explained by economic variables such as interest rates or in ation.
Hens, Thorsten +2 more
core
Multi-issue negotiation under time constraints [PDF]
, 2002 This paper presents a new model for multi-issue negotiation under time constraints in an incomplete information setting. In this model the order in which issues are bargained over and agreements are reached is determined endogenously as part of the ...
Wooldridge, MJ +8 more
core +1 more source
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
A vague theory of choice over time [PDF]
We propose a novel approach to modelling time preferences, based on a cognitive shortcoming of human decision makers: the perception of future events becomes increasingly `blurred' as the events are pushed further in time. Our model explains behavioural `
Paola Manzini, Marco Mariotti
core
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Does Conflict affect Preferences? Results from Field Experiments in Burundi [PDF]
We use experimental data from 35 randomly selected communities in Burundi to examine the impact of exposure to conflict on social-, risk- and time preferences.
Eleonora Nillesen +5 more
core
The impacts of elicitation context on stated preferences for agricultural landscapes
, 2015 Funded by UK Research Council, ESRC, and NERC.Statements of willingness to pay (WTP) have been shown to be dependent upon the framing of the hypothetical market.
Hanley, N. +6 more
core +1 more source
BMC Public HealthBackground Given persistent and unpredictable delays in antiretroviral therapy (ART) initiation globally, this study develops a decision preference scale to identify patients at risk of such delays and evaluates its psychometric properties.
Sisi Fan +5 more
doaj +1 more source