Results 131 to 140 of about 21,021,490 (340)

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

open access: yesFEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe   +5 more
wiley   +1 more source

Preferences Between Continuous Streams of Events [PDF]

open access: yes
Cost-benefit and health policy studies often model a consequence occurring over time as a continuous stream of events. Such a consequence is measured by the rates at which events occur or by the states that occur, and the value of the consequence is ...
Charles M. Harvey, Lars Peter Østerdal
core  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

WP RR 15 - Employees' preferences for more or fewer working hours: The effects of usual, contractual and standard working time, family phase and household characteristics and job satisfaction [PDF]

open access: yes
This study seeks explanations for working time preferences, using cross-sectional multinomial logits for the 2001/2002 Wage Indicator dataset (N=21,727). As expected, the preferences are predominately influenced by working hours’ characteristics, showing
Kea Tijdens
core  

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Dynamic Variational Preferences [PDF]

open access: yes
We introduce and axiomatize dynamic variational preferences, the dynamic version of the variational preferences we axiomatized in [21], which generalize the multiple priors preferences of Gilboa and Schmeidler [9], and include the Multiplier Preferences ...
Fabio Maccheroni   +2 more
core  

Revealed Preferences for Utilitarian Cycling Energy Expenditure versus Travel Time

open access: yesFindings
This paper quantifies the perceived cost of utilitarian cycling energy expenditure as the marginal rate of substitution between energy expenditure and travel time (MRS~et~).
Elmira Berjisian, Alexander Bigazzi
doaj   +1 more source

A group recommendation model integrating time series features

open access: yesXi'an Gongcheng Daxue xuebao
Traditional group recommendation has such problems as ineffective predefined strategy, neglect of the interaction between users and projects, and failure to capture the migration of user preferences caused by the passage of time. In response to the above
ZHU Xinjuan, XIONG Yilun
doaj   +1 more source

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