Results 51 to 60 of about 17,947,053 (276)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Ramadan diurnal intermittent fasting is associated with significant plasma metabolomics changes in subjects with overweight and obesity: A prospective cohort study

Frontiers in Nutrition, 2023
IntroductionDuring the holy month of Ramadan, adult healthy Muslims are mandated to abstain from dawn to sunset, with free eating at night hours that may extend up to 12 h.
Mohamed Madkour, Alexander D. Giddey, Nelson C. Soares, Nelson C. Soares, Nelson C. Soares, Mohammad H. Semreen, Mohammad H. Semreen, Yasser Bustanji, Yasser Bustanji, Falak Zeb, Rabih Halwani, Rabih Halwani, MoezAlIslam E. Faris   +12 more
doaj   +1 more source

Eight-hour time-restricted eating does not lower daily myofibrillar protein synthesis rates: A randomized con of trial

, 2023
Eight-hour time-restricted eating does not lower daily myofibrillar protein synthesis rates: A randomized con of ...
Michael Wheeler (13086588), Joan M Senden (14323485), Joy PB Goessens (14323488), Imre WK Kouw (14323476), Bridget E Radford (14323479), Rebecca C Hall (14323482), Evelyn B Parr (12909761), Luc JC van Loon (11220244), John A Hawley (12909764)   +8 more
core  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Intermittent fasting and neurocognitive disorders: What the evidence shows

The Journal of Nutrition, Health and Aging
Introduction: Intermittent fasting (IF) has emerged as a potential lifestyle intervention for mitigating cognitive decline and enhancing brain health in individuals with mild to major neurocognitive disorders.
Jordan Beveridge, Allison Montgomery, George Grossberg   +2 more
doaj   +1 more source

Effects of Time-Restricted Eating on Cardiometabolic and Cardiovascular Health: Study Protocol (TRES) [PDF]

This study aims to assess the safety, feasibility, and effectiveness of 10-hr Time-Restricted Eating (TRE) compared to ad libitum eating on anthropometric measurements, cardiometabolic and cardiovascular health in patients with Acute Coronary Syndrome ...
Mohd Fahmi Teng, Nur Islami, Kasim, Sazzli Shahlan, Zaman, Mazuin Kamarul, Juliana, Norsham   +3 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Study Explores How Time-Restricted Eating Affects Weight Loss [PDF]

OXFORD, Miss. – Time-restricted eating is the latest craze for people looking to lose weight, but whether it works remains the calorie-burning ...
Turnage, Clara
core   +1 more source

Time restricted feeding is associated with poor performance in specific cognitive domains of Suburb-Dwelling older Chinese

Scientific Reports, 2023
The purpose of this study was to investigate the association between time restricted feeding (TRF) and different areas of cognitive function in the elderly in Chinese communities.
Jiayu Li, Ruijin Li, Xuan Lian, Peipei Han, Yuewen Liu, Chuanchuan Liu, Beibei Wang, Chunliu Xu, Feng Wang, Jingru Wang, Xueling Zheng, Mingyao Shen, Yanan Zha, Bin Mao, Ming Li, Ying Yu, Qi Guo   +16 more
doaj   +1 more source