Results 111 to 120 of about 3,595,948 (318)

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

open access: yesMolecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp   +13 more
wiley   +1 more source

Time-Scale for Accretion of Matter

open access: yesAstrophysics and Space Science, 1999
8 pages, 2 figures, Proceedings of "Galaxy Evolution: Connecting the distant Universe with the local fossil record", Rencontres de Meudon, 21-25 sep 98, ed. M.
openaire   +3 more sources

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

New Criteria for Oscillation of Advanced Noncanonical Nonlinear Dynamic Equations

open access: yesMathematics
In this study, novel criteria are derived to ensure the oscillation of solutions in nonlinear advanced noncanonical dynamic equations. The obtained results are reminiscent of the criteria proposed by Hille and Ohriska for canonical dynamic equations ...
Taher S. Hassan   +3 more
doaj   +1 more source

A System for Recording Air Concentrations of Zinc Sulfide Fluorescent Pigment on a Real-Time Scale [PDF]

open access: bronze, 1967
P.W. Nickola   +3 more
openalex   +1 more source

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

open access: yesMolecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche   +8 more
wiley   +1 more source

Qualitative Outcomes on Monotone Iterative Technique and Quasilinearization Method on Time Scale

open access: yesAxioms
In this paper, a nonlinear dynamic equation with an initial value problem (IVP) on a time scale is considered. First, applying comparison results with a coupled lower solution (LS) and an upper solution (US), we improved the quasilinearization method ...
Şahap Çetin   +2 more
doaj   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner   +6 more
wiley   +1 more source

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