Results 111 to 120 of about 11,420,922 (288)
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Network traffic multi-step prediction based on chaos theory and improved echo state network
Tongxin xuebao, 2016 Network traffic prediction was an important problem of network management and network congestion control.In order to solve this problem,a network traffic prediction method based on chaos theory and improved echo state net-work was proposed.Firstly ...
Zhong-da TIAN +3 more
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Dissipative Kinematics in Binary Neutron Star Mergers
UniverseWe highlight the recent progress in the calculation of transport coefficients pertinent to binary neutron star mergers. Specifically, we analyze the bulk viscosity coefficient driven by both the DURCA and MURCA processes and electron transport ...
Sreemoyee Sarkar, Souvik Priyam Adhya
doaj +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Qualitative Outcomes on Monotone Iterative Technique and Quasilinearization Method on Time Scale
AxiomsIn this paper, a nonlinear dynamic equation with an initial value problem (IVP) on a time scale is considered. First, applying comparison results with a coupled lower solution (LS) and an upper solution (US), we improved the quasilinearization method ...
Şahap Çetin +2 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Multi-Time Scale Analysis of Runoff Variation of Kaidu River over Past 60 Years
Renmin ZhujiangThe pattern analysis of the long-sequence river runoff evolution holds crucial importance for the scientific planning and rational utilization of surface water resources.
WEI Guanghui +3 more
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