Results 171 to 180 of about 3,292,095 (334)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Postsynaptic frequency filters shaped by the interplay of synaptic short-term plasticity and cellular time scales. [PDF]

J Comput Neurosci
Mondal Y, Benito GV, Pena RFO, Rotstein HG.   +3 more
europepmc   +1 more source

Multi-Scale Stochastic Modeling of Dynamics of a Time-Averaged Variable

, 2014
Kaito Umemura, Kuniyoshi Ebina
openalex   +2 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Temperature-dependent trapping and polaron annihilation on ultrafast time scales in metal-halide perovskites. [PDF]

J Phys Chem Lett
Wang J, Park J, Gao L, Virgilio LD, Qu S, Kim H, Wang HI, Wu LL, Zeng W, Bonn M, Ren Z, Geuchies JJ.   +11 more
europepmc   +1 more source

Study on the periodic fluctuations of runoff with multi-time scales based on set pair analysis

, 2018
Yan Ye, Jinping Zhang, Jiachun Yang, Jian Lì   +3 more
openalex   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Fibrin/MoS₂-nanosheet conductive hydrogels with programmed time scales and pathways for bioresorption. [PDF]

Nanoscale Adv
Shukla V, Bilderback WT, Fernandes D, Daley M, Basnet R, Joshi P, Yang Z, Tripathi A, Rosenstein JK, Coulombe K, Hurt RH.   +10 more
europepmc   +1 more source

The Development of Time Management Scale for Primary School Level: Validity and Reliability Study

, 2021
Gülcenur KESEBİR, Gönül SAKİZ
openalex   +1 more source

Hydrological response characteristics of Mediterranean catchments at different time scales: a meta-analysis [PDF]

, 2016
Mohammad Merheb, Roger Moussa, Chadi Abdallah, François Colin, Charles Perrin, Nicolas Baghdadi   +5 more
openalex   +1 more source