Results 181 to 190 of about 802,210 (308)

Decade time scale variability of ventilation in the North Atlantic: High‐precision measurements of bomb radiocarbon in banded corals [PDF]

, 1989
Ellen R. M. Druffel
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Suicidal urges and attempted suicide at multiple time scales in borderline personality disorder. [PDF]

J Affect Disord, 2023
Kaurin A, Dombrovski AY, Hallquist MN, Wright AGC.   +3 more
europepmc   +1 more source

Interaction of the Monsoon and Pacific Trade Wind System at Interannual Time Scales. Part II: The Tropical Band [PDF]

, 1984
T. P. Barnett
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Emergent time scales of epistasis in protein evolution. [PDF]

Proc Natl Acad Sci U S A
Di Bari L, Bisardi M, Cotogno S, Weigt M, Zamponi F.   +4 more
europepmc   +1 more source

Space and Time Scales of Atmospheric Variability [PDF]

, 1981
Michael Stefanick
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Refining Zooplankton Diet Composition Studies Over Short and Long Time Scales by Combining 18S Metabarcoding With Fatty Acid Analyses. [PDF]

Mol Ecol Resour
Pauli NC, Metfies K, Neuhaus S, Graeve M, Cleary AC, Iversen MH, Meyer B.   +6 more
europepmc   +1 more source

Adaptation to changes in COVID-19 pandemic severity: Across older adulthood and time scales. [PDF]

Psychol Aging, 2023
Segerstrom SC, Crosby P, Witzel DD, Kurth ML, Choun S, Aldwin CM.   +5 more
europepmc   +1 more source