Results 61 to 70 of about 9,956,497 (284)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Optimizing Convolutional Neural Network Architectures

Mathematics
Convolutional neural networks (CNNs) are commonly employed for demanding applications, such as speech recognition, natural language processing, and computer vision.
Luis Balderas, Miguel Lastra, José M. Benítez   +2 more
doaj   +1 more source

Persistence in a Stationary Time-series

, 2001
We study the persistence in a class of continuous stochastic processes that are stationary only under integer shifts of time. We show that under certain conditions, the persistence of such a continuous process reduces to the persistence of a ...
A.J. Bray, A.J. Bray, B. Derrida, B. Derrida, B. Derrida, B. Derrida, B. Yurke, C. Godreche, C. Monthus, C. Sire, C.M. Newman, D. Slepian, D. Sornette, D.S. Fisher, Deepak Dhar, E. Ben-naim, E. Ben-Naim, F.J. Dyson, G. De Smedt, G. Manoj, G.P. Wong, H. Kallabis, H.J. Hilhorst, I. Dornic, I.F. Blake, J. Cardy, J. Farago, J. Krug, K. Oerding, M. Howard, M. Marcos-Martin, M.J. Keeling, M.R. Swift, M.W. Lee, O. Deloubriere, O. Deloubriere, P. Collet, P.L. Krapivsky, S. Raychaudhuri, S.J. Cornell, S.N. Majumdar, S.N. Majumdar, S.N. Majumdar, S.N. Majumdar, S.N. Majumdar, S.N. Majumdar, S.N. Majumdar, S.N. Majumdar, S.S. Gupta, Satya N. Majumdar, T.J. Newman, T.J. Newman, T.W. Burkhardt, T.W. Burkhardt, W.Y. Tam, Y.G. Sinai   +55 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Time Series Segmentation Based on Stationarity Analysis to Improve New Samples Prediction

Sensors, 2021
A wide range of applications based on sequential data, named time series, have become increasingly popular in recent years, mainly those based on the Internet of Things (IoT).
Ricardo Petri Silva, Bruno Bogaz Zarpelão, Alberto Cano, Sylvio Barbon Junior   +3 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

An Efficient Green AI Approach to Time Series Forecasting Based on Deep Learning

Big Data and Cognitive Computing
Time series forecasting is undoubtedly a key area in machine learning due to the numerous fields where it is crucial to estimate future data points of sequences based on a set of previously observed values.
Luis Balderas, Miguel Lastra, José M. Benítez   +2 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

CO and CO2 daily time series and time series of wind speed

Data in Brief, 2019
The global CO2 has increased rapidly because of the vast use of fossil fuels over past 40 years. CO, co-emitted with CO2, also increased during this period.
Changgong Shan, Wei Wang
doaj   +1 more source

From turbulence to financial time series

, 1998
We develop a framework especially suited to the autocorrelation properties observed in financial times series, by borrowing from the physical picture of turbulence.
B Holdom, Castaing, Cizeau, Clark, Feller, Frisch, Ghashghaie, Holdom, Kolmorgorov, Liu, Mantegna, Mantegna, Mantegna, Obukhov   +13 more
core   +2 more sources