Results 71 to 80 of about 28,610,872 (373)
FEBS Letters, EarlyView.Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek +15 more
wiley +1 more source
On predicting climate under climate change
Environmental Research Letters, 2013 Can today’s global climate model ensembles characterize the 21st century climate in their own ‘model-worlds’? This question is at the heart of how we design and interpret climate model experiments for both science and policy support.
Joseph D Daron, David A Stainforth
doaj +1 more source
Networks with time structure from time series
, 2012 We propose a method of constructing a network, in which its time structure is directly incorporated, based on a deterministic model from a time series. To construct such a network, we transform a linear model containing terms with different time delays ...
Albert +19 more
core +1 more source
FEBS Letters, EarlyView.To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche +2 more
wiley +1 more source
Targeted model evaluations for climate services: A case study on heat waves in Bangladesh
Climate Risk Management, 2020 Though not a sufficient condition, the ability to reproduce key elements of climate variability over the historical record should be a minimum requirement for placing any confidence in a model’s climate forecasts or projections of climate change.
Hannah Nissan +2 more
doaj
Eddies: Fluid Dynamical Niches or Transporters?–A Case Study in the Western Baltic Sea
Frontiers in Marine Science, 2019 Fluid flows in the ocean have a strong impact on the growth and distribution of planktonic communities. In this case study, we applied a Lagrangian eddy detection and tracking tool and a transfer operator approach to data from a coupled hydrodynamical ...
Rahel Vortmeyer-Kley +5 more
doaj +1 more source
Time Series Classification with Shapelet and Canonical Features
Applied Sciences, 2022 Shapelet-based time series classification methods are widely adopted models for time series classification tasks. However, the high computational cost greatly limits the practicability of the Shapelet-based methods. What is more, traditional Shapelet can
Hai-Yang Liu +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever +1 more
wiley +1 more source
Parsimonious Time Series Clustering
, 2015 We introduce a parsimonious model-based framework for clustering time course data. In these applications the computational burden becomes often an issue due to the number of available observations.
D'Ambrosio, Antonio +3 more
core +1 more source
Molecular Oncology, EarlyView.Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker +14 more
wiley +1 more source