Results 51 to 60 of about 31,033 (265)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

An improved methodology for quantifying causality in complex ecological systems.

PLoS ONE, 2019
This paper provides a statistical methodology for quantifying causality in complex dynamical systems, based on analysis of multidimensional time series data of the state variables.
Hiroko Kato Solvang, Sam Subbey
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Mesoscopic Community Structure of Financial Markets Revealed by Price and Sign Fluctuations. [PDF]

PLoS ONE, 2015
The mesoscopic organization of complex systems, from financial markets to the brain, is an intermediate between the microscopic dynamics of individual units (stocks or neurons, in the mentioned cases), and the macroscopic dynamics of the system as a ...
Assaf Almog, Ferry Besamusca, Mel MacMahon, Diego Garlaschelli   +3 more
doaj   +1 more source

A Review of Mathematical and Computational Methods in Cancer Dynamics

Frontiers in Oncology, 2022
Cancers are complex adaptive diseases regulated by the nonlinear feedback systems between genetic instabilities, environmental signals, cellular protein flows, and gene regulatory networks. Understanding the cybernetics of cancer requires the integration
Abicumaran Uthamacumaran, Hector Zenil, Hector Zenil, Hector Zenil, Hector Zenil, Hector Zenil   +5 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Insights on Streamflow Predictability Across Scales Using Horizontal Visibility Graph Based Networks

Frontiers in Water, 2020
Streamflow is a dynamical process that integrates water movement in space and time within basin boundaries. The authors characterize the dynamics associated with streamflow time-series data from 64 U.S.
Ganesh R. Ghimire, Navid Jadidoleslam, Witold F. Krajewski, Anastasios A. Tsonis, Anastasios A. Tsonis   +4 more
doaj   +1 more source

Against the Flow of Time with Multi-Output Models

Measurement Science Review, 2023
Recent work has paid close attention to the first principle of Granger causality, according to which cause precedes effect. In this context, the question may arise whether the detected direction of causality also reverses after the time reversal of ...
Jakubík Jozef, Phuong Mary, Chvosteková Martina, Krakovská Anna   +3 more
doaj   +1 more source

Time series analysis for multi-dimensional dynamical systems combining wavelet transformation and local principal component analysis [PDF]

Progress of Theoretical and Experimental Physics, 2019
AbstractTo analyze trajectories for systems of many degrees of freedom, we propose a new method called wavelet local principal component analysis (WlPCA) combining the wavelet transformation and local PCA in time. Our method enables us to reduce the dimensionality of time series both in degrees of freedom and frequency so that characteristic features ...
Kana Fuji, Mikito Toda
openaire   +1 more source