Results 71 to 80 of about 338,472 (315)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Process Systems Engineering. A Method of Modeling for Nonlinear Process Dynamics by Chaotic Time-Series Analysis.

KAGAKU KOGAKU RONBUNSHU, 1996
カオス的時系列解析による非線形プロセスのモデリング法を開発した.本手法は, 現時刻近傍の時系列データと類似した過去の時系列データをカオス的時系列解析法により検索し, その挙動から予測値を求める.本法の有効性を検証するため, エチレン装置脱メタン塔の塔底温度制御系に適用した.その結果, 本法は有効であることがわかった.
Yoshitomo Hanakuma, Kazutoyo Nakaya, Takeshi Takeuchi, Takashi Sasaki, Eiji Nakanishi   +4 more
openaire   +2 more sources

Event coincidence analysis for quantifying statistical interrelationships between event time series: on the role of flood events as possible triggers of epidemic outbreaks

, 2016
Studying event time series is a powerful approach for analyzing the dynamics of complex dynamical systems in many fields of science. In this paper, we describe the method of event coincidence analysis to provide a framework for quantifying the strength ...
Donges, Jonathan F., Donner, Reik V., Schleussner, Carl-Friedrich, Siegmund, Jonatan F.   +3 more
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Extracting interpretable signatures of whole-brain dynamics through systematic comparison.

PLoS Computational Biology
The brain's complex distributed dynamics are typically quantified using a limited set of manually selected statistical properties, leaving the possibility that alternative dynamical properties may outperform those reported for a given application.
Annie G Bryant, Kevin Aquino, Linden Parkes, Alex Fornito, Ben D Fulcher   +4 more
doaj   +1 more source

Linear Stochastic Models of Nonlinear Dynamical Systems

, 1998
We investigate in this work the validity of linear stochastic models for nonlinear dynamical systems. We exploit as our basic tool a previously proposed Rayleigh-Ritz approximation for the effective action of nonlinear dynamical systems started from ...
B. A. Finlayson, C. Penland, E. Lorenz, F. Schlögl, F. Schlögl, G. L. Eyink, G. L. Eyink, G. L. Eyink, G. L. Eyink, G. L. Eyink, Gregory L. Eyink, H. Cramér, J. L. Lumley, L. Onsager, L. Onsager, R. H. Kraichnan, R. S. Ellis, S. Machlup   +17 more
core   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Exploring recursive properties and dynamical complexity in scalar time-series using threshold-free recursive analysis approach

AIP Advances
In this project, a threshold-free recursive analysis approach was investigated to reveal the recursive properties of dynamic systems. Specifically, the occurrence of recurrent patterns in phase trajectory was identified by a threshold-free recursive ...
Guodong Sun, Haisheng Wang, Yuting Wang, Bobo Jian   +3 more
doaj   +1 more source

Recurrence time analysis, long-term correlations, and extreme events

, 2005
The recurrence times between extreme events have been the central point of statistical analyses in many different areas of science. Simultaneously, the Poincar\'e recurrence time has been extensively used to characterize nonlinear dynamical systems.
Altmann, Eduardo G., Kantz, Holger
core   +1 more source