Results 51 to 60 of about 1,621,990 (261)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

PPP time transfer using an adaptive clock constraint model

open access: yesGeo-spatial Information Science
In the processing of Precise Point Positioning (PPP) data, the receiver clock is approached with nearly infinite uncertainty, rendering it difficult to fulfill the requirements of high-precision time frequency applications.
Jinyang Han   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

LEO-Enhanced Multi-GNSS Real-Time PPP Time Transfer

open access: yesRemote Sensing
GNSS Precise Point Positioning (PPP) technology has been applied to the time transfer for a long time, enabling time synchronization between two arbitrary stations on a global scale.
Wei Xie   +5 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Comparison of Low-Cost GNSS Receivers for Time Transfer using Zero-Length Baseline

open access: yesMeasurement Science Review
A comparison between low-cost single-frequency and dual-frequency Global Navigation Satellite System (GNSS) receiver timing modules is presented, focusing on their suitability for time transfer applications.
Doršic Marek
doaj   +1 more source

High-Precision Time Transfer Over 2000-km Fiber Link

open access: yesIEEE Photonics Journal, 2015
Manuscript received September 28, 2015; revised October 26, 2015; accepted November 5, 2015. Date of publication November 10, 2015; date of current version November 20, 2015.
Hao Zhang   +4 more
doaj   +1 more source

Inter‐hospital transfer for thrombectomy: transfer time is brain

open access: yesEuropean Journal of Neurology
AbstractBackground and purposePatients with acute ischaemic stroke and a large vessel occlusion who present to a non‐endovascular‐capable centre often require inter‐hospital transfer for thrombectomy. Whether the inter‐hospital transfer time is associated with 3‐month functional outcome is poorly known.MethodsAcute stroke patients enrolled between ...
Seners, Pierre   +5 more
openaire   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Transfer Information Energy: A Quantitative Indicator of Information Transfer between Time Series

open access: yesEntropy, 2018
We introduce an information-theoretical approach for analyzing information transfer between time series. Rather than using the Transfer Entropy (TE), we define and apply the Transfer Information Energy (TIE), which is based on Onicescu’s ...
Angel Caţaron, Răzvan Andonie
doaj   +1 more source

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