Results 211 to 220 of about 16,788,032 (264)

Time trends in colorectal cancer incidence across the BRICS: an age-period-cohort analysis for the GBD 2021. [PDF]

Front Oncol
Zhang C, Chen L, Zhang C, Xiu Y, Zhang H, Ying W, Liu H.   +6 more
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Time : December 24 - 31, 2018

TIME Asia
core  

Time-Trends in Case-Fatality After Acute Myocardial Infarction Among Middle-Aged Lithuanian Adults, 2000-2023: Data from the Population-Based Kaunas Ischemic Heart Disease Register. [PDF]

Medicina (Kaunas)
Radisauskas R, Sileikiene L, Luksiene D, Tamosiunas A, Jasukaitiene E, Augustis S, Kranciukaite-Butylkiniene D.   +6 more
europepmc   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Time trends in post-polypectomy surveillance guideline adherence: analysis of over 90 000 colonoscopies with polypectomy. [PDF]

Endoscopy
Zessner-Spitzenberg J, Penz D, Waldmann E, Bognar F, Unger S, Selinger T, Demschik A, Trauner M, Ferlitsch M.   +8 more
europepmc   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Prevalence, Determinants, and Time Trends of Cardiovascular Health in the WHO African Region.

JAMA Cardiol
Agboyibor KM, Nambiema A, Gbeasor F, Barengo N, Okeibunor JC, Jouven X, Dangou JM, Farzadfar F, Empana JP.   +8 more
europepmc   +1 more source

Statistical Modeling to Adjust for Time Trends in Adaptive Platform Trials Utilizing Non-Concurrent Controls. [PDF]

Biom J
Krotka P, Posch M, Gewily M, Höglinger G, Bofill Roig M.   +4 more
europepmc   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source