Results 101 to 110 of about 808,221 (264)

Optimal Control for an Epidemic Model of COVID-19 with Time-Varying Parameters

Mathematics
The coronavirus disease 2019 (COVID-19) pandemic disrupted public health and economies worldwide. In this paper, we investigate an optimal control problem to simultaneously minimize the epidemic size and control costs associated with intervention ...
Yiheng Li
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

A Square-Root Second-Order Extended Kalman Filtering Approach for Estimating Smoothly Time-Varying Parameters. [PDF]

Multivariate Behav Res, 2022
Fisher ZF, Chow SM, Molenaar PCM, Fredrickson BL, Pipiras V, Gates KM.   +5 more
europepmc   +1 more source

Optimized time varying parameters of the power balance equation model for electric arc furnaces

IET Generation, Transmission & Distribution
An accurate model of electric arc furnaces (EAFs) is required to analyse their impact on the system's power quality. One of the well‐known approaches to model EAF is using the power balance equation.
Zahra Babaei, Haidar Samet
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

[Design and application of neural electrical stimulation system with time-varying parameters]. [PDF]

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi, 2021
Yang G, Feng Z, Zheng L, Wang Z.
europepmc   +1 more source

A Bayesian model calibration framework for stochastic compartmental models with both time-varying and time-invariant parameters

Infectious Disease Modelling
We consider state and parameter estimation for compartmental models having both time-varying and time-invariant parameters. In this manuscript, we first detail a general Bayesian computational framework as a continuation of our previous work ...
Brandon Robinson, Philippe Bisaillon, Jodi D. Edwards, Tetyana Kendzerska, Mohammad Khalil, Dominique Poirel, Abhijit Sarkar   +6 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Age and crack length effects on fracture parameters of dam gallery concrete: Experimental investigation and modeling

Case Studies in Construction Materials
Cracks of varying lengths may occur in galleries throughout dam construction, operation, and management processes. This study investigates the influence of age and crack length on the fracture parameters of gallery concrete, which is crucial for ...
Xiaofeng Gao, Mingli Ji, Yu Hu, Weidong Ruan, Mengxia Zhou, Zhihong Liu   +5 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source