Results 91 to 100 of about 2,034,197 (287)

Robust Optimization for Electric Vehicle Routing Problem Considering Time Windows Under Energy Consumption Uncertainty

open access: yesApplied Sciences
Compared to fossil fuel-based internal combustion vehicles, electric vehicles with lower local pollution and noise are becoming more and more popular in urban logistic distribution.
Dan Wang, Weibo Zheng, Hong Zhou
doaj   +1 more source

A tabu search algorithm for scheduling a single robot in a job-shop environment [PDF]

open access: yes, 1999
We consider a single-machine scheduling problem which arises as a subproblem in a job-shop environment where the jobs have to be transported between the machines by a single transport robot.
Hurink, J.L., Knust, S.
core   +2 more sources

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

Bi-Objective Optimization for Sustainable Logistics in the Closed-Loop Inventory Routing Problem

open access: yesEngineering Proceedings
This study proposes a bi-objective optimization model for the inventory routing problem with pickup and delivery (IRP–PD) in a closed-loop supply chain, addressing the growing demand for sustainable logistics solutions. The model simultaneously minimizes
Chaima Zormati   +3 more
doaj   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

open access: yesFEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel   +8 more
wiley   +1 more source

A Heuristic Algorithm for the Routing and Scheduling Problem with Time Windows: A Case Study of the Automotive Industry in Mexico

open access: yesAlgorithms, 2019
This paper investigates a real-world distribution problem arising in the vehicle production industry, particularly in a logistics company, in which cars and vans must be loaded on auto-carriers and then delivered to dealerships. A solution to the problem
Marco Antonio Juárez Pérez   +4 more
doaj   +1 more source

Reachability cuts for the vehicle routing problem with time windows [PDF]

open access: yes
This paper introduces a class of cuts, called reachability cuts, for the Vehicle Routing Problem with Time Windows (VRPTW). Reachability cuts are closely related to cuts derived from precedence constraints in the Asymmetric Traveling Salesman Problem ...
Lysgaard, Jens
core  

Dynamic programming algorithm for the vehicle routing problem with time windows and EC social legislation [PDF]

open access: yes, 2009
In practice, apart from the problem of vehicle routing, schedulers also face the problem of nding feasible driver schedules complying with complex restrictions on drivers' driving and working hours.
Kok, A. Leendert   +3 more
core   +1 more source

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