Results 121 to 130 of about 16,183,947 (297)

Instalar Windows 8 por pendrive

, 2013
Educação Profissional::Informação e ComunicaçãoMostra como criar um pendrive de instalação do Windows 8 e realizar a instalação a partir dele, configurando a ordem de boot para ...
Ramos, Leandro
core   +2 more sources

Hardware-Aware Sparse QUBO Encoding for CVRPTW on Coherent Ising Machines: An LKH-Guided Variable-Compression Framework

Algorithms
Capacitated vehicle routing with time windows (CVRPTW) is a natural target for coherent Ising machines (CIMs), but a direct multi-vehicle arc encoding scales as O(mN2) and exceeds the variable budget of current CIM-compatible systems.
Zhitao Wu, Zonglin Yang, Jie Zhou, Xuechen Li, Hongmin Wang   +4 more
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Lot-sizing with Production and Delivery Time Windows

, 2005
We study two different lot-sizing problems with time windows that have been proposed recently. For the case of production time windows, in which each client specific order must be produced within a given time interval, we derive tight extended ...
Laurence A. Wolsey, Wolsey, Laurence
core   +1 more source

Formulation and Solution of the Stochastic Truck and Trailer Routing Problem

Engineering Proceedings
In manufacturing and service industries, transportation often faces uncertain conditions. While current research on the truck and trailer routing problem (TTRP) mostly uses deterministic methods, they fall short in addressing uncertainties in travel and ...
Seyedmehdi Mirmohammadsadeghi, Golam Kabir   +1 more
doaj   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Extending the time window for thrombolysis [PDF]

International Journal of Stroke, 2019
Geoffrey A, Donnan, Stephen M, Davis
openaire   +2 more sources

GBS‐MeDIP: A method for the simultaneous identification of genetic and epigenetic variants in tumors

FEBS Open Bio, EarlyView.
GBS‐MeDIP combines DNA sequencing with enrichment of methylated DNA to profile genetic and epigenetic variation in the same reduced genomic fraction. Applied to gastric cancer and parathyroid tumors, it identifies sequence variants, copy number changes, and differentially methylated regions together, helping distinguish true epigenetic changes from ...
Fábio Pértille, Shiva Rezaei, Julia Uffenorde, Oliver Gimm, Mohammad Ali Hosseinpour Feizi, Luiz Lehmann Coutinho, Carlos Guerrero‐Bosagna   +6 more
wiley   +1 more source