Results 41 to 50 of about 14,914 (282)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Electrocution as an alternative euthanasia method to blunt force trauma to the head followed by exsanguination for non-viable piglets

Acta Veterinaria Scandinavica, 2020
Background On farms, the currently approved and most widely practised method of euthanising non-viable piglets is blunt force trauma to the head followed by exsanguination.
Johannes Husheer, Matthias Luepke, Peter Dziallas, Karl-Heinz Waldmann, Alexandra von Altrock   +4 more
doaj   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

A Novel Decellularized Fibrocartilage Graft Promotes Tympanic Membrane Repair

Advanced Healthcare Materials, EarlyView.
An off‐the‐shelf decellularized porcine meniscus fibrocartilage graft (MEND) is engineered for pediatric tympanoplasty. Featuring a microchannel architecture that promotes host cell invasion, MEND rapidly closes tympanic membrane perforations and fully remodels in vivo, outperforming fascia and matching cartilage grafts while avoiding donor‐site ...
Paul M. Gehret, Ryan M. Friedman, Gautham Nair, Stephanie L. Fung, Dana D. Ragbirsingh, John Germiller, Riccardo Gottardi   +6 more
wiley   +1 more source

Clinical, laboratory and ultrasonographic findings in 87 cows with type-4 abomasal ulcer

BMC Veterinary Research, 2019
Background This study evaluated the clinical, laboratory, ultrasonographic and pathological findings in 87 cows aged 2 to 10 years (4.5 ± 1.5 years) with type-4 abomasal ulcer.
Ueli Braun, Christina Reif, Karl Nuss, Monika Hilbe, Christian Gerspach   +4 more
doaj   +1 more source

Experiences of hospital-based multidisciplinary team meetings in oncology : an interview study among participating general practitioners [PDF]

, 2017
Background: Cancer care has become complex, requiring healthcare professionals to collaborate to provide high-quality care. Multidisciplinary oncological team (MDT) meetings in the hospital have been implemented to coordinate individual cancer patients ...
Pype, Peter, Mertens, Fien, Belche, Jeanluc, Duchesnes, Christiane, Kohn, Laurence, Sercu, Marij, Deveugele, Myriam   +6 more
core   +2 more sources

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source

Two Cultures of Caring: A Comparative Study [PDF]

, 2012
There is much that the UK and the US could and should learn from each other to understand the quality of end-of-life care, through comparison of practice, analysis of care patterns and via original research (Higginson, 2005, p.170).
Armstrong, Lisa, Polito, Chistina
core   +1 more source

Aspects and dilemmas of euthanasia in modern times

Scripta Medica
Euthanasia is a very complex medical and moral issue. The name has taken throughout history quite different meanings especially in recent decades. There have been many controversial debates and ethical questions raised in modern society. The aim of the paper was to introduce in more detail the issue of euthanasia in the modern world and to review the ...
Alen Greš, Dijana Staver, Ljubomir Radovančević   +2 more
openaire   +2 more sources