Results 61 to 70 of about 424,131 (275)

Landscape review about the decision to euthanize a compromised pig

Porcine Health Management
Timely euthanasia of a compromised pig in farming practice has been identified as a critical topic in veterinary medicine. The questions ‘why and when are pigs euthanized’ and ‘what influences the decision making process’ need to be answered to improve ...
J. Stoffregen, T. Winkelmann, B. Schneider, K. Gerdes, M. Miller, J. Reinmold, C. Kleinsorgen, K. H. Toelle, L. Kreienbrock, E. grosse Beilage   +9 more
doaj   +1 more source

In Situ Genetic Engineering Facilitates MMP‐9‐Responsive TIMP1 Release Through Proteolytic Cleavage to Boost Diabetic Wound Healing

Advanced Science, EarlyView.
This study develops an MMP‐9‐responsive protein release system that transforms resident cells into drug depots through in situ genetic engineering. Anchored to the membrane, the therapeutic protein TIMP1 is selectively released upon MMP‐9 cleavage.
Yuan Zhang, Jiani Deng, Man Yee Cheung, Tingting Fu, Xufeng Qi, Dongqing Cai, Jianmin Sun, Gang Lu, Peng Shi, Wai‐Yee Chan, Xu Li, Hui Zhao   +11 more
wiley   +1 more source

Burrowing Behavior as Robust Parameter for Early Humane Endpoint Determination in Murine Models for Pancreatic Cancer

Animals
Due to late-stage diagnoses and limited treatment options, pancreatic cancer is predicted to be the second leading cause of cancer deaths by 2030. Many different murine models were developed over the past decades to test new therapies for this tumor ...
Jakob Brandstetter, Lisa Hoffmann, Ingo Koopmann, Tim Schreiber, Benjamin Schulz, Stephan Patrick Rosshart, Dietmar Zechner, Brigitte Vollmar, Simone Kumstel   +8 more
doaj   +1 more source

Deciphering Anti‐Cancer Drug Efficacy Through Nanomechanical Vibrations in Living Gastric Cancer Organoids

Advanced Science, EarlyView.
This study developed an efficacy assessment platform that integrates patient‐derived gastric cancer organoids, atomic force microscopy (AFM)‐based nanomechanical vibration detection, deep learning analysis, and organoid mechanical modeling. It detects picomolar drug effects within 0.1 s signal, achieves 97% classification accuracy, and offers non ...
Ting Zhang, Qiubo Chen, Shihai Lan, Liang Zhu, Shuaiyu Liu, Yan Xia, Yalu Zhang, Hanhui Yao, Yongman Liu, Shangquan Wu, Qingchuan Zhang   +10 more
wiley   +1 more source

An Analysis of New York State's Medical Aid in Dying Act (A. 2383A S. 3151)

Voices in Bioethics, 2018
Introduction An amended version of the proposed Medical Aid in Dying Act (A. 2383A S. 3151) was recently filed with the New York State legislature [1].
Michael Dauber
doaj   +1 more source

Historical Review of Euthanasia. From Ancient Times until before Modern Times

Maedica - A Journal of Clinical Medicine
The historical review of euthanasia shows the pivotal role played by Christianity in the perceptions and attitudes towards it. In ancient Greece and Rome, euthanasia was rejected by medicine, but philosophy and ethics supported it as an attitude to life.
A, Spinthouraki, S N, Michaleas, I, Nikolakakis, G, Marinos, I, Dimitriadis, M, Karamanou   +5 more
openaire   +2 more sources

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Euthanasia, Ethics and Economics

, 1990
The financial aspects of legalizing active euthanasia rarely have been discussed. Hayry and Hayry argue that there are no good grounds for ignoring the connection between euthanasia and the need to conserve medical resources. Their paper is intended to
Hayry, Heta, Hayry, Matti
core   +1 more source

m6A‐Driven Pexophagy Triggers Placental Ferroptosis to Impair Fetal Growth Upon Environmental Stress

Advanced Science, EarlyView.
Prenatal environmental stress exposure promotes m6A modification to drive PEX2‐dependent pexophagy, thereby causing placental ferroptosis and FGR. ABSTRACT The role and underlying mechanisms of placental ferroptosis in fetal growth restriction (FGR) induced by environmental stress remain poorly understood.
Xin‐Xin Zhang, Ye‐Xin Luo, Cheng‐Fang Sun, Rui Pan, Yu‐Xi Wu, Zhi Yuan, Xin‐Run Wang, Xu‐Dong Zhang, Lan‐Lan Wu, Xiang‐Yu Yao, Zhan‐Dong Song, Wei Chang, Tian Wei, Pan‐Yuan Cai, Tian‐Ci Zhang, Yong‐Wei Xiong, De‐Xiang Xu, Hua Wang, Hua‐Long Zhu   +18 more
wiley   +1 more source

Pulmonary Thromboembolism and Myocarditis Resulting from a Large Pacing-Lead-Associated Right Ventricular Thrombus in a Dog with Chronic Cough as Presenting Sign

Veterinary Sciences
In the present case report, we describe the clinical course and postmortem findings of a 12-year-old Labrador retriever dog with a third-degree atrio-ventricular block that developed a chronic cough, and later dyspnea and weakness as a result of massive ...
Viktor Szatmári, Rachel Thomas
doaj   +1 more source