Results 101 to 110 of about 1,407,102 (317)

Genome organization of DNA replication timing and its link to chromatin and transcription [PDF]

, 2008
The replication of the genome is a highly organized process. Not every sequence replicates at the same time, instead some genes replicate early, while others replicate later during S phase.
Schwaiger, Michaela
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

The role of multiple neuromodulators in reinforcement learning that is based on competition between eligibility traces

Frontiers in Synaptic Neuroscience, 2016
The ability to maximize reward and avoid punishment is essential for animal survival. Reinforcement learning (RL) refers to the algorithms used by biological or artificial systems to learn how to maximize reward or avoid negative outcomes based on past ...
Marco A Huertas, Sarah Elizabeth Schwettmann, Harel Z Shouval   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Self-Confidence and Timing of Entry [PDF]

This paper analyzes the impact of overconfidence on the timing of entry in markets, profits, and welfare. To do that the paper uses an endogenous timing model where (i) players have private information about costs and (ii) one player is overconfident and
Tiago Pires, Luís Santos-Pinto
core  

Multiple-interval timing in rats: Performance on two-valued mixed fixed-interval schedules

, 2003
Three experiments studied timing in rats on two-valued mixed-FI schedules, with equally probable components, FI S and FI L. When the L/S ratio was greater than 4, two distinct response peaks appeared close to FI S and L, and data could be well-fitted ...
Whitaker, Simon, Whitaker, S., Lowe, Furgus, Wearden, John, Lowe, C. F., Wearden, J. H.   +5 more
core   +1 more source

Constraining the size, shape, and albedo of the large trans-Neptunian object (28978) Ixion with multi-chord stellar occultations

Astronomy & Astrophysics
Context. Trans-Neptunian objects (TNOs) are among the most primitive remnants of the early Solar System. Determining their sizes, shapes, albedos, and surface properties is essential for understanding their origin and evolution.
Kilic Y., Braga-Ribas F., Pereira C. L., Ortiz J. L., Sicardy B., Santos-Sanz P., Erece O., Rizos J. L., Gómez-Limón J. M., Margoti G., Souami D., Morgado B., Gomes-Junior A., Catani L. M., Desmars J., Kretlow M., Rommel F., Duffard R., Alvarez-Candal A., Camargo J. I. B., Kaplan M., Morales N., Herald D., Assafin M., Benedetti-Rossi G., Sfair R., Savalle R., Arcas-Silva J., Bernasconi L., Blank T., Bonavita M., Carlson N., Christophe B., Colesanti C. A., Collins M., Columba G., Dunford R., Dunham D. W., Dunham J., Emilio M., Ferrante W. G., George T., Hanna W., Isopi G., Jones R., Kenyon D. A., Kerr S., Kouprianov V., Maley P. D., Mallia F., Mattei J., Meunier M., Napoleao T., Peixoto V. F., Pollock J., Snodgrass C., Stechina A., Thomas W., Venable R., Viscome G. R., Zapparata A., Bardecker J., Castro N., Cebral C., Chapman A., Gao C., Green K., Guimaraes A., Jacques C., Jehin E., Konishi M., Leiva R., Liberato L., Magliano C., Mammana L. A., Melita M., Moura V., Olivera-Cuello Y., Peiro L., Spagnotto J., Stuart P. C., Vanzi L., Wilberger A., Malacarne M.   +83 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Timing and Self-Control [PDF]

, 2013
The dual self-model of self-control with one-period lived short-run selves is excessively sensitive to the timing of shocks and to the interpolation of additional “noaction” time periods in between the dates when decisions are made.
Levine, David K., Fudenberg, Drew
core   +1 more source