Results 151 to 160 of about 19,573 (307)

Timing characterization of MALTA and MALTA2 pixel detectors using Micro X-ray source

The MALTA monolithic active pixel detector is developed toaddress some of the challenges anticipated in future high-energyphysics detectors. As part of its characterization, we conductedtiming studies necessary to provide a figure of merit for thisfamily
Vijay, A., Gonella, L., Asensi Tortajada, I., Snoeys, W., Pernegger, H., Berlea, D.V., Nunez, M. Vazquez, Buttar, C., Behera, P., Flores Sanz de Acedo, L., Worm, S., Weick, J., Allport, P., Gustavino, G., Inada, T., Li, L.; id_orcid, Vazquez Nunez, M., Riedler, P., Dao, V., Gazi, M., Haberl, S., Bortoletto, D., van Rijnbach, M., Jana, P., Fasselt, L., Gonzalez, V., Dash, G., Solans Sanchez, C.A., de Acedo, L. Flores Sanz, Li, L.   +29 more
core   +2 more sources

PIZZICATO: Picosecond Scintillator Timing with Superconducting Nanowire Single-Photon Detectors

, 2020
Time-of-flight positron emission tomography (TOF-PET) visualizes molecular processes in vivo and is commonly used in the treatment of cancer. TOF-PET can be transformed into a tool for personalized medicine in a much wider range of clinical applications ...
Schaart, Dennis R., Dorenbos, Sander N., Zadeh, Iman Esmaeil, Chang, Jin, Krämer, Karl, Dorenbos, Pieter, Siebbeles, Laurens D.A.   +6 more
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

PPS Performance: first evaluation of the two-arm vertex resolution with timing detectors in 2023

The Precision Proton Spectrometer (PPS) is a forward-proton spectrometer using near-beam detectors (inside Roman Pots, RPs) located symmetrically on both sides of IP5 at a distance of about 220 m.
CMS Collaboration
core  

Thin LG AD timing detectors for the ATLAS experiment [PDF]

, 2019
El gran col· lisionador de hadrons (LHC), el qual te un circumferencia de 27 quilometres, és l'accelerador de partícules més gran i potent del món. El LHC esta dissenyat per fer col· lisionar protons a 14 TeV en el seu centre de massa, aconseguint
Carulla Areste, Maria del Mar
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

PPS Performance 2024 Efficiency and two-arm vertex resolution with timing detectors

The Precision Proton Spectrometer (PPS) is a forward-proton spectrometer using near- beam detectors (inside Roman Pots, RPs) located symmetrically on both sides of IP5 at a distance of about 220 m. In addition to the tracking system, the timing detectors
CMS Collaboration
core  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Fast timing methods for semiconductor detectors. Revision

, 1984
This tutorial paper discusses the basic parameters which determine the accuracy of timing measurements and their effect in a practical application, specifically timing with thin-surface barrier detectors.
Spieler, H.
core