Results 141 to 150 of about 19,573 (307)

Front-End Prototype ASIC with Low-Gain Avalanche Detector Sensors for the ATLAS High Granularity Timing Detector

Particles
Timing measurements are critical for the detectors at the future HL-LHC, to resolve reconstruction ambiguity when the number of simultaneous interactions reaches up to 200 per bunch crossing.
Salah El Dine Hammoud
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Beam test results of a 16 ps timing system based on ultra-fast silicon detectors

, 2016
In this paper we report on the timing resolution obtained in a beam test with pions of 180 GeV/c momentum at CERN for the first production of 45 µm thick Ultra-Fast Silicon Detectors (UFSD). UFSD are based on the Low-Gain Avalanche Detector (LGAD) design,
Ravera, F., Staiano, A., Mulargia, R., Merlos, A., Minafra, N., Gruey, B., Galloway, Z., Pellegrini, G., Mandic, I., Mikuz, M., McKinney-Martinez, F., Carulla, M., Mandurrino, M., Woods, N., McKinney Martinez, F., Wilder, M., Zatserklyaniy, A., Sadrozinski, H. F. -W., Losakul, R., Cenna, F., Cindro, V., Grabas, H., Ferrero, M., Bellora, A., Cirio, R., Flores, D., Labitan, C.A., Monaco, V., Arcidiacono, R., Durando, S, Durando, S., Sadrozinski, H. F. W., Labitan, C. A., Seiden, A., Spencer, E., Freeman, P., Obertino, M., Quirion, D., Cartiglia, N., Flores, D, Kramberger, G., Sacchi, R., Zavrtanik, M., Sola, V., Luce, Z., Hidalgo, S., Fadeyev, V., Gkougkousis, E., ARCIDIACONO, Roberta   +48 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

PROPERTIES OF BORON IMPLANTED LGAD TIMING DETECTORS

, 2018
For the high luminosity upgrade of the Large Hadron Collider (HL-LHC) at CERN starting in the middle of 2026 after the 3r d long shutdown. The HL-LHC will be operating at √s = 14 TeV and reaching a peak instantaneous luminosity of 5 x 1034 cm−2 s−1 (7.5 ...
Elgendy, Hoda Elsayed Fahmy
core  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Editorial: Precision detectors and electronics for fast timing: Advances and applications

Frontiers in Physics, 2023
Arianna Morozzi, Giovanni Calderini
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source