Results 131 to 140 of about 19,573 (307)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Study of the Timing Characteristics in Coaxial Ge(Li) Detectors [PDF]

, 1969
This thesis deals with the theory and application of semi-conductor detectors to timing measurements. The theory section discusses the charge collection times in the coaxial detector.
Panagiotopoulos, Georgia Binikou
core  

Identification of prompt fission γ-rays with lanthanum-chloride scintillation detectors

, 2012
In this paper we demonstrate the employment of LaCl3:Ce scintillation detectors for the identification of prompt fission γ-rays from γ-radiation in contrast to other reactions. We present the properties of cylindrical 1.5 in. 71.5 in.
Karlsson, J., Geerts, W., F.-J. Hambsch, Oberstedt, Stephan,, R. Billnert, Karlsson, J.,, J. Karlsson, Geerts, W.,, Billnert, R.,, Oberstedt, S.,, Oberstedt, S., W. Geerts, Hambsch, F. -J., S. Oberstedt, Oberstedt, Andreas,, A. Oberstedt, Billnert, Robert, Hambsch, F. -J.,, Oberstedt, Andreas, Billnert, Robert,   +19 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Ultra precise timing with SiPM-based TOF PET scintillation detectors

, 2009
The combination of SiPMs with fast and bright scintillators, such as LaBr3:Ce, seems very promising for application in time-of-flight (TOF) PET. We therefore conducted a series of experiments with the goal of obtaining the best possible timing resolution
Van Dam, Herman T., Schaart, Dennis R., Herbert Lohner, Peter Dendooven, Ruud Vinke, Dendooven, Peter, Löhner, Herbert, Beekman, Freek J., Seifert, Stefan, Stefan Seifert, Freek J. Beekman, Vinke, Ruud, Herman T. van Dam, Dennis R. Schaart   +13 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Two new decision directed M-PSK timing error detectors

, 2005
This paper shall introduce two new Decision Directed timing error detectors for symbol synchronization circuits in M-PSK receivers. The first detector is a modification of the Gardner timing error detector and requires a sampling rate of 2 samples/symbol.
Yair Linn
core  

The use of timing detectors for beam characterization at the Muon Ionization Cooling Experiment

, 2010
The Muon Ionization Cooling Experiment is designed to demonstrate the operation of a module of a cooling channel by observing individual particles of a beam with the properties found in a Neutrino Factory.
Rayner, M A
core   +1 more source