Results 121 to 130 of about 13,975,826 (243)

Dual variational methods for time-harmonic nonlinear Maxwell’s equations

Nonlinear Differential Equations and Applications NoDEA
Abstract We prove the existence of infinitely many nontrivial solutions for time-harmonic nonlinear Maxwell’s equations on bounded domains and on $$\mathbb {R}^3$$
openaire   +2 more sources

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Variational Iteration Method for the Time-Fractional Elastodynamics of 3D Quasicrystals

Computer Modeling in Engineering & Sciences, 2012
This paper presents the approximate analytical solutions to the time fractional differential equations of elasticity for 3D quasicrystals with initial conditions. These equations are written in the form of a vector partial differential equation of the second order.
openaire   +3 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

A review of autonomous reef monitoring structures (ARMS) for monitoring hard‐bottom benthic biodiversity

Methods in Ecology and Evolution
Amid increasing anthropogenic pressures on ecosystems, standardised biodiversity monitoring is critical for assessing biodiversity change. Marine hard‐bottom habitats, though ubiquitous and biodiverse, present challenges for biodiversity monitoring due ...
Aaron Jessop, Margaux Steyaert, Nauras Daraghmeh, Justine Pagnier, Melody S. Clark, Lloyd S. Peck, Keiron P. P. Fraser   +6 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Management of fetal umbilical vein varix: a survey-based analysis of current clinical practice

Archives of Gynecology and Obstetrics
Objective To evaluate current diagnostic criteria, risk stratification, and management practices for fetal intra-abdominal umbilical vein varix (FIUVV) among maternal–fetal medicine and obstetric ultrasound specialists in Israel.
Rachelle Fraenkel Merzbach, Reut Rotem, Dan V. Valsky, Hen Y. Sela, Simcha Yagel, Misgav Rottenstreich   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source