Results 251 to 260 of about 958,468 (325)

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Validity and Reliability of Portable Blood Lactate Analyzers: A Systematic Review with COSMIN and GRADE Assessment. [PDF]

Sports Med Open
Bruno J, Thapa RK, Santos Â, Montoro-Bombú R, Sarmento H.   +4 more
europepmc   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Spatial overlap and temporal synchrony between guilds of insect hosts and parasitoids. [PDF]

J Anim Ecol
van Dijk LJA, Goodsell RM, Andersson AF, Fisher BL, Iwaszkiewicz-Eggebrecht E, Lukasik P, Miraldo A, Peña-Aguilera P, Ronquist F, Roslin T, Tack AJM.   +10 more
europepmc   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Dynamic tracking of breastfeeding and weaning in carbon isotopes of tooth enamel. [PDF]

iScience
Kimura Y, Cerling TE, Yamada K, Seki A, Casanovas-Vilar I, Flynn LJ, Jacobs LL.   +6 more
europepmc   +1 more source

Patterns of care and outcomes following external ventricular drain placement: Insights from the England HES administrative data set. [PDF]

Brain Spine
Thompson D, Wahba A, Williams A, Hutchinson P, Helmy A, Cromwell D.   +5 more
europepmc   +1 more source

Blood Transfusion Risk Following Early Versus Delayed Surgery in Hip Fracture Patients on Direct Oral Anticoagulants: A Study Protocol for a Natural Experiment. [PDF]

J Clin Med
Schiepers T, Smeeing D, Wijnen H, Willems H, Wijdicks FJ, Flikweert E, Kempen D, Bosma E, Hegeman JH, Emmelot-Vonk M, van der Velde D, Schuijt HJ.   +11 more
europepmc   +1 more source