Results 221 to 230 of about 1,365,383 (280)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Interfacial engineering via dipolar fullerene derivative for efficient tin halide perovskite indoor photovoltaics. [PDF]

Nat Commun
Xiao H, Cui E, Wang J, Liu T, Wei X, Huang J, Abdel-Shakour M, Li J, Wang C, Zhu Z, Meng X.   +10 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Antibacterial properties of experimentally produced birch tar and its medicinal affordances in the Pleistocene. [PDF]

PLoS One
Siemssen T, Oludare A, Schemmel M, Puschmann J, Bierenstiel M.   +4 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Effect of Laser Energy Density During LPBF on the Structure and Mechanical Properties of Al-15Sn-5Pb Alloy. [PDF]

Materials (Basel)
Rusin NM, Skorentsev AL, Akimov KO, Likharev VE, Il'yashchenko DP, Dmitriev AI.   +5 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Chiral Plasmonic Surface Temperature Switching by Several Tens of Kelvins in Titanium Nitride Nanostructures. [PDF]

Nano Lett
Setoura K, Oshikiri T, Tamura M, Morita K, Fujiwara H, Ishii S, Fujii Y, Matsuo Y, Iida T, Imura K.   +9 more
europepmc   +1 more source

Long-Term Outcomes of IgM-Positive Plasma Cell Tubulointerstitial Nephritis. [PDF]

Kidney Int Rep
Takahashi N, Yoshida H, Kimura H, Yamamoto C, Yamamoto M, Iwamura N, Matsuta K, Nishikawa S, Nishimori K, Fukushima S, Nishikawa Y, Kobayashi M, Kasuno K, Naiki H, Iwano M, Toyama T.   +15 more
europepmc   +1 more source

Tumor-infiltrating neutrophil is an independent prognostic factor in pancreatic ductal adenocarcinoma. [PDF]

Diagn Pathol
Son SM, Han HS, Lee HC, Lee OJ, Woo CG.
europepmc   +1 more source