Results 231 to 240 of about 547,273 (359)

Design of low bandgap tin–lead halide perovskite solar cells to achieve thermal, atmospheric and operational stability

Nature Energy, 2019
R. Prasanna, T. Leijtens, Sean P. Dunfield, James A. Raiford, Eli J. Wolf, Simon A. Swifter, J. Werner, G. Eperon, Camila de Paula, A. Palmstrom, Caleb C. Boyd, M. Van Hest, S. Bent, G. Teeter, J. Berry, M. McGehee   +15 more
semanticscholar   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Spatiotemporal activation of unfolded protein response by combined sonodynamic therapy and proteasome inhibition with bortezomib-conjugated TiN nanoparticles. [PDF]

Bioact Mater
Yin D, Wu X, Chen JL, An K, Fang Y, Xiong HM, Wang L, Huang C, Zhu GY, Cheng L, Wang J, Zhu XM.   +11 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Polydopamine-doped PEDOT interfaces improve cell-electrode interactions and neural signal transmission. [PDF]

Sci Rep
Ahmadi Seyedkhani S, Kalhor S, Iraji Zad A, Vafaiee M, Taghipoor M, Mohammadpour R.   +5 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Conducting multicenter trials through the trial innovation network comprehensive consultation. [PDF]

Contemp Clin Trials
Hanley DF, Lane K, McBee N, Eyzaguirre LM, Mould WA, Holthouse E, Baird JF, Casey JD, Wilkins CH, Waddy SP, Wiley KL, Hassani S, Hildreth M, Nanni A, Edwards TL, Thompson DD, Stroud M, Serdoz E, Kennedy N, Nelson SJ, Jones M, Boone LR, Lawrence C, Cook SK, Chen T, Cohen J, Dilts N, Cheng AC, Grout RW, Miller ER, Casella JF, Benjamin DK, Selker HP, Palm ME, Poole L, Burr JS, Ford DE, Bernard GR, Harris PA.   +38 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Case Report: Pulmonary alveolar proteinosis and fibrosis associated with indium-tin-oxide exposure. [PDF]

Front Med (Lausanne)
Li X, Shi C, Chen Q, Zhao J, Wang S, Yin Y, Feng R, Tian X, Xu KF.   +8 more
europepmc   +1 more source

Lead‐Free Inverted Planar Formamidinium Tin Triiodide Perovskite Solar Cells Achieving Power Conversion Efficiencies up to 6.22%

Advances in Materials, 2016
Weiqiang Liao, Dewei Zhao, Yue Yu, C. Grice, Changlei Wang, A. Cimaroli, P. Schulz, Weiwei Meng, K. Zhu, R. Xiong, Yanfa Yan   +10 more
semanticscholar   +1 more source