Results 91 to 100 of about 832 (140)
Some of the next articles are maybe not open access.
Pharmacokinetics of oral tiopronin
European Journal of Clinical Pharmacology, 1993Ten healthy subjects were given 500 mg (3064 mumol) tiopronin, or 2-mercaptopropionylglycine (2-MPG) by mouth. Cmax was reached after 3-6 h, and after a shorter beta-phase a long terminal half-life of 53 h of total tiopronin was found. Tiopronin measured as unbound (non-protein-bound) drug disappeared more rapidly from plasma, with a calculated t1/2 of
B Kågedal, T Denneberg
exaly +3 more sources
Tiopronin-induced lichenoid eruption
Journal of the American Academy of Dermatology, 1994Sulfhydryl drugs such as D-penicillamine or captopril have many side effects, notably cutaneous eruptions. 1-3Tiopronin (Thiola.Acadione) is a sulfhydryl drug that is prescribed primarily for the treatment of cystinuria. It was recently proposed for the treatment of rheumatoid arthritis. Its efficacy is comparable to D-penicillamine.
E, Piérard +6 more
openaire +2 more sources
Some pharmacological properties of tiopronin
Agents and Actions, 1981Tiopronin (50 mg/kg) and D-penicillamine (50 mg/kg) do not exhibit anti-inflammatory effects in classic animal models (carragenin oedema, granuloma cotton pellets) but suppress pertussis vaccine oedema, an immunological model, when given with a long-lasting dosing regime.
openaire +2 more sources