Results 131 to 140 of about 5,625 (178)

Alternative mechanisms for tiotropium

Pulmonary Pharmacology and Therapeutics, 2009
Tiotropium is commonly used in the treatment of chronic obstructive pulmonary disease. Although largely considered to be a long-acting bronchodilator, its demonstrated efficacy in reducing the frequency of exacerbations and preliminary evidence from early studies indicating that it might slow the rate of decline in lung function suggested mechanisms of
Eric Bateman, Pj Barnes, Klaus F Rabe
exaly   +3 more sources

Tiotropium

Tijdschrift voor praktijkondersteuning, 2015
Tiotropium is het eerste langwerkende inhaleerbare parasympathicolyticum dat sinds 2001 internationaal beschikbaar is gekomen voor de behandeling van chronisch obstructieve luchtwegaandoeningen (COPD). In dit artikel worden de geregistreerde indicatie, de beschikbare handelsvormen, het werkingsmechanisme, de werkzaamheid en bijwerkingen beschreven, en ...
Dick Bijl, Kenny van Deventer
openaire   +1 more source

The Future for Tiotropium

Chest, 2000
In spite of growing interest in and knowledge about the causes and progression of COPD, neither the assessment nor pharmacologic treatment of this condition is currently ideal. Tiotropium is the first new treatment for COPD in many years. Tiotropium is a long-acting anticholinergic agent that has a potential role as a once-daily maintenance treatment ...
openaire   +2 more sources

Tiotropium in asthma

The Lancet Respiratory Medicine, 2015
To the Editor: Kerstjens et al. (Sept. 27 issue)1 report a 21% reduction in the risk of asthma exacerbation associated with tiotropium, along with a significant but small improvement in the forced expiratory volume in 1 second (FEV1), which was less than the minimal clinically important difference of 230 ml.2 We think it is hard to explain the effect ...
openaire   +3 more sources

Tiotropium bromide

Expert Opinion on Investigational Drugs, 2001
Tiotropium bromide is a new long-lasting anticholinergic drug which, like ipratropium bromide, is a quaternary ammonium derivative. It binds with high affinity to muscarinic receptors but dissociates very slowly from M(1)- and M(3)-muscarinic receptors.
openaire   +2 more sources

The Pharmacological Properties of Tiotropium

Chest, 2000
Tiotropium is a long-acting anticholinergic drug. Studies with cloned human muscarinic receptors show that tiotropium binds equally well to M(1), M(2), and M(3) receptors. However, it dissociates very slowly from M(1) and M(3) receptors compared with ipratropium, and more rapidly from M(2) receptors.
openaire   +2 more sources

Tiotropium for Asthma — Promise and Caution

New England Journal of Medicine, 2012
Anticholinergic agents have been available for the treatment of airways obstruction for many decades. For patients with chronic obstructive pulmonary disease (COPD), many practitioners believe that these drugs have become the bronchodilator of choice.
openaire   +2 more sources

Tiotropium in the Treatment of Patients with Asthma

Southern Medical Journal, 2014
Asthma is a chronic disease with a significant disease burden, and many patients fail to achieve disease control despite recommended medical therapy. Recent evidence suggests that there may be benefits to the use of the long-acting anticholinergic agent tiotropium in patients with asthma.We performed a systematic review of the literature to determine ...
Qura, Rashid, Robin, Klein
openaire   +2 more sources

The Safety of Tiotropium — The FDA's Conclusions

New England Journal of Medicine, 2010
Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide, and the rate of COPD-related death is increasing.1 No current drug therapy alters the progressive decline in lung function that characterizes this disease. In 2004, the Food and Drug Administration (FDA) approved the use of tiotropium delivered by the HandiHaler device,
Theresa M, Michele, Simone, Pinheiro, Solomon, Iyasu   +2 more
openaire   +2 more sources

Tiotropium

Nursing, 2021
openaire   +1 more source