Results 1 to 10 of about 964 (170)

A Comparison of the Molecular Pharmacological Properties of Current Short, Long, and Ultra-Long-Acting β₂-Agonists Used for Asthma and COPD. [PDF]

Pharmacol Res Perspect
ABSTRACT β‐agonists have been used in asthma for 120 years. There are two recent changes: ultra‐long‐acting agonists for COPD and new asthma guidelines recommending formoterol/ICS inhalers phasing out short‐acting salbutamol inhalers. Few studies directly compare the molecular pharmacological properties of short (salbutamol, terbutaline, fenoterol ...
Proudman RGW, Baker JG.
europepmc   +2 more sources

Effect of 12 weeks of once-daily tiotropium/olodaterol on exercise endurance during constant work-rate cycling and endurance shuttle walking in chronic obstructive pulmonary disease

Therapeutic Advances in Respiratory Disease, 2018
Background: The TORRACTO ® study evaluated the effects of tiotropium/olodaterol versus placebo on endurance time during constant work-rate cycling and constant speed shuttle walking in patients with chronic obstructive pulmonary disease (COPD) after 12 ...
Denis O'Donnell, Dave Singh, Anne-Marie Kirsten   +2 more
exaly   +2 more sources

Cost-Effectiveness Analysis of Fixed-Dose Tiotropium/Olodaterol versus Tiotropium for COPD Patients in China. [PDF]

Int J Chron Obstruct Pulmon Dis, 2023
Ying Lan,1 Nan Yang,2 Yirong Wang,1 Yan Yang,1 Min Xu,1 Qin He1 1Department of Pharmacy, Affiliated Hospital of Southwest Jiaotong University, the Third People’s Hospital of Chengdu, Chengdu, Sichuan, 610031, People’s Republic of China; 2West China ...
Lan Y, Yang N, Wang Y, Yang Y, Xu M, He Q.   +5 more
europepmc   +2 more sources

Therapeutic Success of Tiotropium/Olodaterol, Measured Using the Clinical COPD Questionnaire (CCQ), in Routine Clinical Practice: A Multinational Non-Interventional Study

International Journal of COPD, 2021
Arschang Valipour,1 Sergey Avdeev,2 Adam Barczyk,3 Valentina Bayer,4 Zvi Fridlender,5 Mariela Georgieva,6 Ondřej Kudela,7 Alexey Medvedchikov,8 Ramona Miron,9 Maria Sanzharovskaya,8 Virginija Šileikienė,10 Jurij Šorli,11 Marc Spielmanns,12 ...
Zsuzsanna Szalai, Alexey Medvedchikov, Sergey Avdeev   +2 more
exaly   +2 more sources

Assessment of drug permeability using a small airway microphysiological system. [PDF]

Front Pharmacol
BackgroundThere is a need to reliably predict the permeability of inhaled compounds during the development of new and generic drugs. A small airway microphysiological system (MPS) that can recapitulate the pulmonary air-liquid interface (ALI) with ...
Geiger RM, Rahman SM, Rashid Roni MS, Sullenberger C, Mistry S, Shea K, Tariq I, Ismaiel OA, Matta MK, Hyland PL, Berdichevski S, Ribeiro AJS, Blinova K, Jiang W, Walenga RL, Newman B, Volpe DA, Ford KA.   +17 more
europepmc   +2 more sources

Respiratory maze: An anatomical variant of tracheal bronchus. [PDF]

Respirol Case Rep
Tracheal bronchus is a rare congenital abnormality of bronchial variation arising from trachea. Special attention should be paid during intubation as it can potentially obstruct the bronchus. Key message This case highlights an uncommon anatomical variation in the airway known as Tracheal bronchus, which can sometimes lead to recurrent pneumonia. It is
Gullapalli D, Tangutoori S, Ganti SS.
europepmc   +2 more sources

Tiotropium/Olodaterol treatment reduces cigarette smoke extract-induced cell death in BEAS-2B bronchial epithelial cells

BMC Pharmacology and Toxicology, 2020
Background Cigarette smoking is a critical risk factor for the destruction of lung parenchyma or the development of emphysema, which is characteristic of COPD.
Cheng-hsiung Chen, Yi-Rong Li, Sheng-Hao Lin, Hsiu-Hui Chang, Woei-Horng Chai, Po-Chiang Chan, Ching-Hsiung Lin   +6 more
doaj   +1 more source

Cost-effectiveness of the fixed-dose combination tiotropium/olodaterol versus tiotropium monotherapy or a fixed-dose combination of long-acting β2-agonist/inhaled corticosteroid for COPD in Finland, Sweden and the Netherlands: a model-based study

BMJ Open, 2021
Objectives Chronic obstructive pulmonary disease (COPD) guidelines advocate treatment with combinations of long-acting bronchodilators for patients with COPD who have persistent symptoms or continue to have exacerbations while using a single ...
Maureen Rutten-van Mölken, Martine Hoogendoorn, Isaac Corro Ramos, Stéphane Soulard, Jennifer Cook, Erkki Soini, Emma Paulsson   +6 more
doaj   +1 more source

Predicting the duration of action of β2‐adrenergic receptor agonists: Ligand and structure‐based approaches

Molecular Informatics, Volume 42, Issue 12, December 2023., 2023
Abstract Agonists of the β2 adrenergic receptor (ADRB2) are an important class of medications used for the treatment of respiratory diseases. They can be classified as short acting (SABA) or long acting (LABA), with each class playing a different role in patient management.
Luca Chiesa, Emilie Sick, Esther Kellenberger   +2 more
wiley   +1 more source

Honokiol ameliorates cigarette smoke‐induced damage of airway epithelial cells via the SIRT3/SOD2 signalling pathway

Journal of Cellular and Molecular Medicine, Volume 27, Issue 24, Page 4009-4020, December 2023., 2023
Abstract Cigarette smoking can cause damage of airway epithelial cells and contribute to chronic obstructive pulmonary disease (COPD). Honokiol is originally isolated from Magnolia obovata with multiple biological activities. Here, we investigated the protective effects of honokiol on cigarette smoke extract (CSE)‐induced injury of BEAS‐2B cells.
Fei Li, Chunyu Ye, Xiuli Wang, Xinting Li, Xiaoxia Wang   +4 more
wiley   +1 more source