Results 61 to 70 of about 72,876 (262)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

The flagella connector of Trypanosoma brucei : an unusual mobile transmembrane junction. [PDF]

, 2004
Throughout its elongation, the new flagellum of the procyclic form of the African trypanosome Trypanosoma brucei is tethered at its tip to the lateral aspect of the old flagellum.
Sue Vaughan, Vaughan, Sue, Vaughan, S, Davidge, J, Moreira-Leite, Flavia, Keith Gull, Baines, A, Flavia Moreira-Leite, McKean, PG, Gull, K, Moreira-Leite, F, Jacqueline Davidge, Baines, Andrea, Briggs, Laura, Gull, Keith, Laura J. Briggs, McKean, Paul G., Paul G. McKean, Davidge, Jacqueline, Briggs, LJ, Andrea Baines   +20 more
core   +1 more source

High-Precision Extraction Method for Blade Tip-Timing Signal with Eddy Current Sensor

International Journal of Rotating Machinery, 2020
Online monitoring of high-speed rotating blades has always been a hot topic. Of the various methods, the blade tip timing (BTT) technique, based on eddy current sensors, is considered to be the most promising.
Ji-wang Zhang, Ke-qin Ding, Guang Chen
doaj   +1 more source

Effectiveness Analysis on Human-Machine Information Interaction of Intelligent Highway

Journal of Advanced Transportation, 2022
Different human-machine collaboration modes and driving simulation tests with the orthogonal method considered are designed for a series of typical intelligent highway landscapes.
Yicheng Zhou, Tuo Sun, Shunzhi Wen, Hao Zhong, Youkai Cui, Jiemin Xie, Wei Wu, Wanjing Ma   +7 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Tip-timing data analysis for mistuned bladed discs assemblies

, 2008
International audienceIn turbomachine industry, bladed assembly vibration measurements are very important for blades behaviour estimation. These measurements are generally obtained from strain gauges.
Arnaud Talon, Stephan, Cyrille, Marc Berthillier, Lardiès, Joseph, Joseph Lardie`s, Talon, Arnaud, Cyrille Ste´phan, Berthillier, Marc   +7 more
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

BTT & RFLB - THE OPTIMUM SET FOR STEAM TURBINE BLADES MONITORING

Acta Polytechnica CTU Proceedings, 2018
BTT, Blade Tip Timing system, is a commercially available system generating files of precise times of blade tips when passing sensors attached in a machine stator.
Miroslav Balda
doaj   +1 more source