Distinct functions of TIR1 and AFB1 receptors in auxin signalling [PDF]
Molecular Plant, 2023 Auxin is the major plant hormone regulating growth and development (Friml, 2022). Forward genetic approaches in the model plant Arabidopsis thaliana have identified major components of auxin signalling and established the canonical mechanism mediating ...
Huihuang Chen +4 more
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TIR1-produced cAMP as a second messenger in transcriptional auxin signalling. [PDF]
NatureThe phytohormone auxin (Aux) is a principal endogenous developmental signal in plants. It mediates transcriptional reprogramming by a well-established canonical signalling mechanism.
Chen H +7 more
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Role of cAMP in TIR1/AFB auxin signaling: open issues.
Trends in Plant ScienceThe canonical mechanism by which the phytohormone auxin regulates transcription has been one of the cornerstones of plant signaling. The recent unexpected discovery of cyclic AMP (cAMP) as a second messenger in this pathway has revised its foundations ...
Jiří Friml
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Auxin-independent depletion of degron-tagged proteins by TIR1
microPublication biology, 2020 (https://www.micropublication.org/media/2020/01/Screen-Shot-2020-01-11-at-5.29.58-PM.png) Figure 1: A. Example side-by-side micrograph of FLAG::degron::ERFA-3 and degron::ERFA-3;TIR1 adult animals.
Erin C. Schiksnis +5 more
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A super sensitive auxin-inducible degron system with an engineered auxin-TIR1 pair [PDF]
Nucleic Acids Research, 2020 Auxin-Inducible Degron (AID) technology enables conditional depletion of targeted proteins. However, the applicability of the AID in vertebrate cells has been limited due to cytotoxicity caused by high auxin concentrations. Here, we establish an improved
K. Nishimura +8 more
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Role of TIR1/AFB family genes during grafting in Carya cathayensis
Frontiers in Plant ScienceAuxins play significant roles in plant growth and development. The transporter inhibitor response1/auxin signaling F-box (TIR1/AFB) gene family encodes the auxin receptor proteins and plays an essential role in the auxin signaling pathway.
Jiaqi Mei +13 more
doaj +4 more sources
Chemical hijacking of auxin signaling with an engineered auxin-TIR1 pair [PDF]
Nature Chemical Biology, 2017 The phytohormone auxin, indole-3-acetic acid (IAA), regulates nearly all aspects of plant growth and development. Despite substantial progress in our understanding of auxin biology, delineating specific auxin response remains as a major challenge.
N. Uchida +13 more
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A Populus TIR1 gene family survey reveals differential expression patterns and responses to 1-naphthaleneacetic acid and stress treatments [PDF]
Frontiers in Plant Science, 2015 The plant hormone auxin is a central regulator of plant growth. TRANSPORT INHIBITOR RESPONSE 1/AUXIN SIGNALING F-BOX (TIR1/AFB) is a component of the E3 ubiquitin ligase complex SCFTIR1/AFB and acts as an auxin co-receptor for nuclear auxin signaling ...
Wenbo eShu +8 more
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The role of Phe82 and Phe351 in auxin-induced substrate perception by TIR1 ubiquitin ligase: a novel insight from molecular dynamics simulations. [PDF]
PLoS ONE, 2010 It is well known that Auxin plays a key role in controlling many aspects of plant growth and development. Crystal structures of Transport inhibitor response 1 (TIR1), a true receptor of auxin, were very recently determined for TIR1 alone and in complexes
Ge-Fei Hao, Guang-Fu Yang
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AgronomyTIR1/AFB proteins are a class of auxin receptors with key roles in plant development and biotic and abiotic stress responses; several have been identified as targets of the auxin-mimicking herbicide picloram.
Wenchao Du +10 more
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