Results 61 to 70 of about 8,055 (251)
Peptide Marriages: Modular Assembly of Multi‐Agonist Therapeutics
Chemistry – A European Journal, EarlyView.A modular polyethylene glycol (PEG) scaffold enables rapid assembly of dual peptide agonists using strain‐promoted azide–alkyne cycloaddition (SPAAC) and copper‐catalysed azide–alkyne cycloaddition (CuAAC). Glucagon‐like peptide‐1 (GLP‐1) and amylin agonists were combined with controlled valency, yielding low‐picomolar activity and receptor‐selective ...
Kristina A. Kostadinova +11 more
wiley +1 more source
Process for the preparation of Tirzepatide [PDF]
Title of the invention: Process for the preparation of Tirzepatide The present invention relates to a process for the preparation of Tirzepatide represented by the following structural formula-1. Formula-
, Srinivasan Thirumalai Rajan, Ghojala Venkat Reddy, Mallepally Venkat Reddy, Suryapeta Srinivas, Nidadavolu Chandrasekhar, MSN Laboratories Private Limited, R&D Center, Hyderabad, India.
core +1 more source
Journal of Magnetic Resonance Imaging, EarlyView.ABSTRACT Background Epicardial adipose tissue (EAT) is a metabolically active fat depot associated with cardiovascular risk and represents a modifiable imaging biomarker. Studies have shown that sodium–glucose cotransporter‐2 (SGLT2) inhibitors reduce EAT thickness in patients with type 2 diabetes mellitus (T2DM). However, it is unclear whether this is
Min Jae Cha +9 more
wiley +1 more source
Tirzepatide and potential use for metabolically healthy obesity.
, 2023 Metabolically healthy obesity or metabolically healthy overweight (MHO) is best described as being absent of any major metabolic disorder or cardiovascular diseases such as type 2 diabetes mellitus, dyslipidemia, hypertension, and atherosclerotic ...
Yavuz, Furkan +4 more
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Vitreous hemorrhage in a patient on tirzepatide: Coincidence or drug induced?
Oman Journal of OphthalmologyTirzepatide is a synthetic polypeptide classified as glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 receptor agonist. It stimulates insulin secretion from the pancreas and helps lower blood sugar levels in patients with type 2 ...
Sitara Azeem +2 more
doaj +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver disease worldwide, closely linked to the global rising incidence of obesity and metabolic syndrome. This review synthesizes current evidence on the pathogenesis, gut–liver axis, and multidisciplinary management of MASLD within the ...
Beom Kyung Kim
wiley +1 more source
A Rare Case of Tirzepatide-Induced Hepatitis: Causality Assessment With the RUCAM Criteria
Annals of Internal Medicine: Clinical CasesTirzepatide is an effective medication that targets both glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptors, resulting in weight loss, improved glycemic control, and better cardiovascular and renal outcomes.
Rayan Tareg Ahmed +3 more
doaj +1 more source
Reasons for discontinuing tirzepatide in randomized controlled trials: A systematic review and meta-analysis [PDF]
Despite therapeutic benefits, discontinuation of tirzepatide is common in randomized controlled trials (RCTs) due to adverse events (AEs) and other causes. No previous systematic reviews have explored the reasons for discontinuing tirzepatide in the RCTs.
Lakshmi Nagendra (24116538) +5 more
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Association of Glucagon‐Like Peptide—1 Receptor Analogues and Laryngeal Symptoms in Obese Adults
The Laryngoscope, EarlyView.Table 1 succinctly quantifies the time‑dependent association between GLP‑1RA/GIP therapy and laryngeal symptoms, demonstrating modest but statistically robust increases in outcomes such as cough and voice/resonance disorders by 6 months. It provides clinically actionable absolute risks, odds ratios, and hazard ratios that can directly inform counseling,
Priyanka Shah +4 more
wiley +1 more source