Results 261 to 270 of about 18,381,159 (295)

Single-Cell Protein Expression Profiling Resolves Circulating and Resident Memory T Cell Diversity Across Tissues and Infection Contexts

Immunity, 2023
Memory CD8+ T cells can be broadly divided into circulating (TCIRCM) and tissue-resident memory T (TRM) populations. Despite well-defined migratory and transcriptional differences, the phenotypic and functional delineation of TCIRCM and TRM cells ...
Florent Ginhoux, Allison Clatch
exaly   +2 more sources

The Multifaceted Role of Tissue-Resident Memory T Cells

Annual Review of Immunology
Regionalized immune surveillance relies on the concerted efforts of diverse memory T cell populations. Of these, tissue-resident memory T (T RM ) cells are strategically positioned in barrier tissues, where they enable efficient frontline defense against infections and cancer.
Susan Christo, Scott N. Mueller, Laura K. Mackay   +2 more
exaly   +3 more sources

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Tissue-resident memory T cells in the skin

Inflammation Research, 2020
Tissue-resident memory T (TRM) cells are a newly described subset of memory T cells. The best characterized TRM cells are CD8+ and express CD103 and CD69. These cells are non-recirculating and persist long term in tissues, providing immediate protection against invading pathogens.
Samar Khalil, Tara Bardawil, Mazen Kurban, Ossama Abbas   +3 more
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Tissue-resident memory T cells in the urogenital tract

Nature Reviews Nephrology, 2022
Our understanding of T cell memory responses changed drastically with the discovery that specialized T cell memory populations reside within peripheral tissues at key pathogen entry sites. These tissue-resident memory T (TRM) cells can respond promptly to an infection without the need for migration, proliferation or differentiation.
Loreto Parga-Vidal, Michiel C. van Aalderen, Regina Stark, Klaas P. J. M. van Gisbergen   +3 more
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Tissue-Resident Memory T Cells in Cancer Immunosurveillance

Trends in Immunology, 2019
Following their activation and expansion in response to foreign threats, many T cells are retained in peripheral tissues without recirculating in the blood. These tissue-resident CD8+ memory T (TRM) cells patrol barrier surfaces and nonlymphoid organs, where their critical role in protecting against viral and bacterial infections is well established ...
Simone L, Park, Thomas, Gebhardt, Laura K, Mackay   +2 more
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Human circulating and tissue-resident memory CD8+ T cells

Nature Immunology, 2023
Our current knowledge of human memory CD8+ T cells is derived largely from studies of the intravascular space. However, emerging data are starting to challenge some of the dogmas based on this work, suggesting that a conceptual revision may be necessary.
Marcus Buggert, David A. Price, Laura K. Mackay, Michael R. Betts   +3 more
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Tissue-Resident Memory T Cells in Allergy

Clinical Reviews in Allergy & Immunology
Tissue-resident memory T (TRM) cells constitute a distinct subset within the memory T cell population, serving as the vanguard against invading pathogens and antigens in peripheral non-lymphoid tissues, including the respiratory tract, intestines, and skin.
Bojin, Long, Shican, Zhou, Yawen, Gao, Kai, Fan, Ju, Lai, Chunyan, Yao, Jingwen, Li, Xiayue, Xu, Shaoqing, Yu   +8 more
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Behavior and Function of Tissue-Resident Memory T cells

2012
Our understanding of memory T cell function in mice and men is to date in large part restricted to the behavior of circulating memory T cells. Emerging evidence, however, suggests that in addition to such systemic memory T cell populations, a separate population of locally confined memory T cells is generated at former sites of antigen encounter. Here,
Silvia, Ariotti, John B, Haanen, Ton N, Schumacher   +2 more
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