Results 111 to 120 of about 6,554,877 (306)
Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix
FEBS Letters, EarlyView.The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual +3 more
wiley +1 more source
BCTB FFPE (Formalin Fixed Paraffin Embedded) Blocks
This BCTB tissue subcollection consists of FFPE (Formalin Fixed Paraffin Embedded) blocks: pieces of tissue fixed in formalin, dehydrated and embedded into wax, then thinly sliced for viewing under a microscope.
core
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
BCTB Non-Invasive Breast Cancer Samples and Images
This BCTB subcollection contains breast tissue and blood samples, and associated images, where a diagnosis of non-invasive cancer has been determined by a ...
core
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
BCTB Invasive Breast Cancer Samples and Images
This BCTB subcollection contains breast tissue and blood samples, and associated images, where a diagnosis of invasive cancer has been determined by a ...
core
Principles of tissue engineering /
, 2007 First published in 1997, Principles of Tissue Engineering is the widely recognized definitive resource in the field. The third edition provides a much needed update of the rapid progress that has been achieved in the field, combining the prerequisites ...
Vacanti, Joseph. +2 more
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FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
, 2006 Beginnings of Blessed Virgin Mary in ink. King bearing gift on reverse side [Tissue Sketches 346.B].Tiff file: 1747x582 pixels, 2.91 Mb; Display: jpeg, 419x140 pixels ...
Father Edward Catich
core +1 more source
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source