Results 91 to 100 of about 139,523 (305)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Informativeness of phenotypic features of connective tissue dysplasia in children with peritoneal adhesions

Galician Medical Journal, 2016
Connective tissue dysplasia can be realized with a large number of clinical variants, and accordingly, excessive postoperative adhesion formation can be considered as a manifestation of dysplastic-dependent processes.
M. G. Melnichenko, A. A. Kvashnina
doaj   +1 more source

Tissue engineering: construction of a multicellular 3D scaffold for the delivery of layered cell sheets. [PDF]

, 2014
Many tissues, such as the adult human hearts, are unable to adequately regenerate after damage.(2,3) Strategies in tissue engineering propose innovations to assist the body in recovery and repair. For example, TE approaches may be able to attenuate heart
McCloskey, Kara E, Sandhu, Nabjot, Turner, William S   +2 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Predicting Intra-Abdominal Adhesions in Repeat Cesarean Sections: Scar Tissue Characteristics, Striae Gravidarum, and Corset Use

Clinical and Experimental Obstetrics & Gynecology
Background: This study evaluated whether abdominal scar tissue characteristics, duration of corset use, and striae gravidarum (SG) density are associated with the severity of intra-abdominal adhesions (IAA) in repeat cesarean sections (
Yusuf Ziya Kizildemir, Hacer Uyanikoglu, Ömer Tammo, Mehmet İncebiyik, Bekir Kahveci   +4 more
doaj   +1 more source

Effectiveness of Seprafilm in Reducing Postoperative Adhesions after Abdominopelvic Surgery: A Prospective Interventional Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Postoperative adhesions are indeed a significant concern following abdominopelvic surgeries. These fibrous bands of tissue can form between abdominal or pelvic organs and tissues, leading to various complications.
M Malarmannan, A Pravindhas, Debarath Das, R Lakshmana, N Soorya, N Snigdha   +5 more
doaj   +1 more source

Antiadhesive Nanofibrous Materials for Medicine: Preventing Undesirable Tissue Adhesions. [PDF]

ACS Omega, 2023
Klicova M, Rosendorf J, Erben J, Horakova J.   +3 more
europepmc   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

NETworking for Health and in Disease: Neutrophil Extracellular Traps in Pediatric Surgical Care

Children
This comprehensive review examines the role of Neutrophil Extracellular Traps (NETs) in pediatric surgery. Focusing on NET formation, functions, and implications, this study highlights their dual impact in infection control and contribution to tissue ...
Maximilian Dölling, Martin Herrmann, Michael Boettcher   +2 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source