Results 91 to 100 of about 97,379 (308)

Modified Adenovirus Reduces De Novo Peritoneal Adhesions in Rats and Limits Off-Target Transfection. Role of EZH2 in Adhesion Formation

Journal of Investigative Surgery, 2017
Aim of the study: Adenovector encoding tissue plasminogen activator (tPA) was shown to reduce experimental peritoneal adhesion. We investigated the targeting potential of our modified adenovector, its ability to reduce adhesions and the epigenetic role ...
Hussein M. Atta, Ayman A. Al-Hendy, Salama R. Abdel Raheim, Hend Abdel-Ghany, Khalid A. Nasif, Ahlam M. Abdellah, Nagwa M. Zenhom, Heba S. Kamel   +7 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The role of matrix rhythm therapy in managing and breaking tissue adhesions

This article explores the potential of Matrix Rhythm Therapy (MRT) in addressing tissue adhesions, focusing on its relevance as a non-invasive and effective treatment modality.
Asthana, Sumit, Rizvi, Arif, Naqvi, Zia Abbas, Fatima, Tahzeeb   +3 more
core   +1 more source

Sprayable tissue adhesive with biodegradation tuned for prevention of postoperative abdominal adhesions

, 2022
Adhesions are dense, fibrous bridges that adjoin tissue surfaces due to uncontrolled inflammation following postoperative mesothelial injury. A widely used adhesion barrier material in Seprafilm often fails to prevent transverse scar tissue deposition ...
Selim Rozyyev, Anthony D. Sandler, Ayyub, Omar B., Sandler, Anthony D., Peter Kofinas, John L. Daristotle, Daristotle, John L., Metecan Erdi, Erdi, Metecan, Rozyyev, Selim, Kofinas, Peter, Saruwatari, Michele S., Michele S. Saruwatari, Omar B. Ayyub, Manogna Balabhadrapatruni, Balabhadrapatruni, Manogna   +15 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

[Adhesions and abdominal pain]

, 2011
Adhesions occur with a high incidence after intra-abdominal surgery but can also develop due to infections, radiation or for idiopathic reasons. The formation of adhesions is initiated by tissue damage and is the result of peritoneal tissue repair ...
Studer, Peter, Mennicke, Maria, Inderbitzin, Daniel   +2 more
core  

Surgical Management of Intrauterine Adhesions

, 2023
Intrauterine adhesions, also known as Asherman’s syndrome, can have an impact on both reproductive outcomes and gynaecologic symptoms. Surgical management with hysteroscopic lysis of adhesions is the gold standard for treatment.
Xiaowu Huang
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Effectiveness of Seprafilm in Reducing Postoperative Adhesions after Abdominopelvic Surgery: A Prospective Interventional Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Postoperative adhesions are indeed a significant concern following abdominopelvic surgeries. These fibrous bands of tissue can form between abdominal or pelvic organs and tissues, leading to various complications.
M Malarmannan, A Pravindhas, Debarath Das, R Lakshmana, N Soorya, N Snigdha   +5 more
doaj   +1 more source

Antiadhesive Nanofibrous Materials for Medicine: Preventing Undesirable Tissue Adhesions. [PDF]

ACS Omega, 2023
Klicova M, Rosendorf J, Erben J, Horakova J.   +3 more
europepmc   +1 more source