Results 81 to 90 of about 139,523 (305)

Adhesive and mechanical regulation of mesenchymal stem cell differentiation in human bone marrow and periosteum-derived progenitor cells [PDF]

, 2012
It has previously been demonstrated that cell shape can influence commitment of human bone marrow-derived mesenchymal stem cells (hBMCs) to adipogenic, osteogenic, chondrogenic, and other lineages.
Chen, Christopher S., Eyckmans, Jeroen, Lin, Grace L.   +2 more
core   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Virtual cardiac monolayers for electrical wave propagation [PDF]

, 2017
The complex structure of cardiac tissue is considered to be one of the main determinants of an arrhythmogenic substrate. This study is aimed at developing the first mathematical model to describe the formation of cardiac tissue, using a joint in silico ...
Agladze, Konstantin, Kudryashova, Nina, Panfilov, Alexander, Tsvelaya, Valeriya   +3 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Two-photon imaging of cancer cell extravasation in live mice [PDF]

, 2011
MDA-MB-231 breast cancer cells were engineered to express cytoplasmic paxillin-GFP and nuclear H2B-mCherry. In order to image extravasation, the cancer cells were injected in the blood stream of nude mice.
Aguilar, Jose S, Digman, Michelle A, Gratton, Enrico, Hoffman, Robert M, Suetsugu, Atsushi   +4 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Pregnancy Complication Caused by Migrated Injectable Breast Filler: A Case Report

Clinical and Experimental Obstetrics & Gynecology
Background: Minimally invasive cosmetic procedures, including soft tissue filler injections, are increasingly performed worldwide.
Hyo Jin Lee, Jin Young Bae
doaj   +1 more source

Modified Adenovirus Reduces De Novo Peritoneal Adhesions in Rats and Limits Off-Target Transfection. Role of EZH2 in Adhesion Formation

Journal of Investigative Surgery, 2017
Aim of the study: Adenovector encoding tissue plasminogen activator (tPA) was shown to reduce experimental peritoneal adhesion. We investigated the targeting potential of our modified adenovector, its ability to reduce adhesions and the epigenetic role ...
Hussein M. Atta, Ayman A. Al-Hendy, Salama R. Abdel Raheim, Hend Abdel-Ghany, Khalid A. Nasif, Ahlam M. Abdellah, Nagwa M. Zenhom, Heba S. Kamel   +7 more
doaj   +1 more source

Elastic interactions of active cells with soft materials

, 2003
Anchorage-dependent cells collect information on the mechanical properties of the environment through their contractile machineries and use this information to position and orient themselves.
A.K. Harris, A.K. Harris, B. Geiger, B. Geiger, C.-M. Lo, C.G. Galbraith, D. Choquet, D. Riveline, F. Grinnell, G.F. Oster, H. Wagner, I. B. Bischofs, I.B. Bischofs, J.L. Tan, J.P. Butler, J.Y. Wong, K.H. Lau, L.J. Walpole, M. Dembo, M. Dembo, M.E. Chicurel, N. Phan-Thien, N. Wang, N.Q. Balaban, P. Lenz, R. Siems, R.-P. Hirsekorn, R.A. Simha, R.D. Mindlin, R.J. Pelham, S. A. Safran, S. Huang, S. Ramaswamy, S.A. Safran, T. Tlusty, U. S. Schwarz, U.S. Schwarz, U.S. Schwarz, V.H. Barocas   +38 more
core   +1 more source

Tensin links energy metabolism to extracellular matrix assembly. [PDF]

, 2017
The regulation of integrin function is key to fundamental cellular processes, including cell migration and extracellular matrix (ECM) assembly. In this issue, Georgiadou et al. (2017. J. Cell Biol.
Calderwood, Emmanuel Dornier, Hardie, Hardie, Horton, Jim C. Norman, McCleverty, Muranen, Pankov, Rainero, Rantala, Rowe, Schiller, Singh, Van Obberghen-Schilling, Yamada   +15 more
core   +3 more sources