Results 61 to 70 of about 97,379 (308)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

From Bench to Bedside: Hydrogel Platforms Bridging Anti‐Adhesion Barriers, Tissue Regeneration, and Personalized Postoperative Recovery

MedComm – Biomaterials and Applications
Postoperative adhesions represent a prevalent complication following surgical interventions, commonly forming between soft tissue surfaces within body cavities. These adhesions can give rise to severe consequences, such as chronic pain, organ dysfunction,
Ting Wang, Hanchao Zhou, Jiangchuan He, Yunhe Zheng, Jinpeng Wen, Yu Huang, Kailai Liu, Yuchen Zhang, Ke Wang   +8 more
doaj   +1 more source

An Adhesive/Anti‐Adhesive Janus Tissue Patch for Efficient Closure of Bleeding Tissue with Inhibited Postoperative Adhesion

Advanced Science, 2023
AbstractMost of the current bioadhesives cannot perform well on bleeding tissues while postoperative adhesion is a general but serious clinical issue. Here, a three‐layer biodegradable Janus tissue patch (J‐TP) that is able to simultaneously enable efficient closure of bleeding wounds with significantly promoted clotting ability and suppressed ...
Wan Peng, Cheng Liu, Youjin Lai, Yanting Wang, Pingsheng Liu, Jian Shen   +5 more
openaire   +3 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Human peritoneal adhesions show evidence of tissue remodeling and markers of angiogenesis

, 2006
PURPOSE: This study was designed to investigate the vascular structure and angiogenic activity of human peritoneal adhesions. METHODS: Adhesions were collected from patients undergoing laparotomy (n = 32).
Herrick, Sarah E.; id_orcid, Ireland, Grenham, O'Dwyer, Sarah T., Wilson, Malcolm S., Epstein, Jonathan C., Wilkosz, Sylwia   +5 more
core   +1 more source

Mechanical stretching enhances TGF-β3 and CREB expression to reduce tendon adhesion during tendon healing in rats

Di-san junyi daxue xuebao, 2019
Objective To evaluate the effect of mechanical stretching in promoting tendon healing and reducing tendon adhesion during the healing of extensor flexor tendon in rats and its effects on the expression of transforming growth factor-β3 (TGF-β3) and cyclic
LI Shuaifeng, QIU Hongjiu, XIE Chuanjiang, LIAO Shiliang, XIONG Yan   +4 more
doaj   +1 more source

α2β1 integrins spatially restrict Cdc42 activity to stabilise adherens junctions

BMC Biology, 2021
Background Keratinocytes form the main protective barrier in the skin to separate the underlying tissue from the external environment. In order to maintain this barrier, keratinocytes form robust junctions between neighbouring cells as well as with the ...
Jake D. Howden, Magdalene Michael, Willow Hight-Warburton, Maddy Parsons   +3 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Development of a novel postoperative adhesion induction model in cynomolgus monkeys with high reliability and reproducibility

Scientific Reports
Postoperative adhesions frequently occur following abdominal surgical interventions, leading to serious morbidities and requiring new therapeutic strategies.
Kenji Nakagawa, Masaki Yamazaki, Hiromi Tanimura, Narumi Sakaguchi, Miho Kohara, Izumi Sato, Masahiro Azuma, Ayako Nishimoto-Kakiuchi, Atsuhiko Kato, Takehisa Kitazawa, Ryo Konno, Tadashi Sankai   +11 more
doaj   +1 more source

Bronchial anastomosis with a tissue adhesive

The Journal of Thoracic and Cardiovascular Surgery, 1987
Air leakage and necrotic degeneration may occur after bronchial anastomosis and can lead to death from secondary pneumothorax and pneumonia. We studied the ability of a new tissue adhesive (N-butyl-cyanoacrylate monomer) to enforce the bronchial suture line.
M, Hachida, P, Naruns, S, Morris, I, Irie, A J, Cochran, D L, Morton   +5 more
openaire   +2 more sources