Results 51 to 60 of about 97,379 (308)

Prevention of Adhesions by PL/PG after Adhesiolysis

, 2012
Background: Previous studies of differently charged polypeptides, Poly-L-lysine (PL) and Poly-L-Glutamate (PG) have shown promising results, reducing postoperative adhesions.
Andersson, Roland, Isaksson, Karolin,, Åkerberg, Daniel,, Bauden, Monika,, Andersson, Roland,, Bauden, Monika, Åkerberg, Daniel, Tingstedt, Bobby,, Isaksson, Karolin, Tingstedt, Bobby, Lund University.   +10 more
core   +1 more source

Morphological features and molecular mechanisms in peritoneal adhesions from patients with chronic abdominal postoperative painResearch in context

EBioMedicine
Summary: Background: Chronic abdominal pain affects 10–20% of all patients following abdominal surgery, with adhesions as a predominant cause. However, the biological mechanisms underlying adhesion-related pain are not fully elucidated. This study aimed
Masja Karina Toneman, Priscilla Pauline Marianne Faas, Maurits Johan Christian Antoine Marie Gielen, Valentina Carotti, Anne Elisa Adriana van Oirschot, Judith Petronella Maria Mangnus, Anne Wintjens, Casper Mihl, Josephine Huige, Bianca Grosser, Marjolein Blussé van Oud-Alblas, Koen Willem van Dongen, Nicole Dorine Bouvy, Harry van Goor, Daniel Keszthelyi, Heike Irmgard Grabsch, Richard Peter Gerardus ten Broek   +16 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Biomimetic hierarchical nanofibrous surfaces inspired by superhydrophobic lotus leaf structure for preventing tissue adhesions [PDF]

, 2022
Undesirable tissue adhesions remain one of the most common and dreaded postoperative complications. Biocompatible nanofibrous mats with antiadhesive surfaces represent a promising barrier method for preventing the formation of adhesions.
Palek, Richard, Liska, Vaclav, Erben, Jakub, Zvercova, Iveta, Klicova, Marketa, Hejda, Matěj, Chvojka, Jiri, Mullerova, Jana, Krejcik, Michal, Rosendorf, Jachym, Novak, Ondrej, Horakova, Jana, Fucikova, Anna, Klapstova, Andrea, Oulehlova, Zuzana   +14 more
core  

Surgical adhesions after laparoscopic myomectomy: methods of prevention [PDF]

, 2023
Objective. Adhesions are one of the most common complications of myomectomy and subsequent surgical procedures. Laparoscopic myomectomy is a low-risk procedure, with an adhesion rate of 50%, unlike laparotomy which has increased rates of 94%. The primary
Palumbo, M., Cafas, V., Boccia, D., Della Corte, L., Viciglione, F., Serafino, P., Mercorio, A., Bifulco, G., Giampaolino, P., Ascione, M.   +9 more
core   +1 more source

Autologous Fat Grafting With Botulinum Toxin For Facial Deformities

International Dental Journal
Aim or purpose: This study evaluates the efficacy of autologous fat grafting combined with botulinum toxin (BTX) injection in improving fat survival and restoring facial contours, especially in cases with soft tissue deficiencies, scars, and subcutaneous
Xi Gong
doaj   +1 more source