Results 71 to 80 of about 15,688 (284)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Tough and Biocompatible Hydrogel Tissue Adhesives Entirely Based on Naturally Derived Ingredients

, 2023
Hydrogel tissue adhesives have tremendous potential applications in biological engineering. Existing hydrogel tissue adhesives generally do not have adequate mechanical robustness and acceptable biocompatibility at the same time.
Canhui Yang (1865539), Haihui Zhang (1511128), Hao Zhong (1756825), Yuenan Wang (10904754), Ziyi Xu (10836260), Peiwu Qin (2120776), Yuan Huang (79836), Sibo Cheng (17702153)   +7 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Clinical, mechanical, and immunohistopathological effects of tissue adhesives on the colon: An in-vivo study

, 2017
Background: Tissue adhesives may be useful for sealing bowel anastomoses by preventing anastomotic leakage. Prior to clinical implementation, an in-depth analysis of the clinical and immunohistopathological effects of tissue adhesives on the target ...
Jeekel, J. (Johannes), Dodou, D. (Dimitra), Lange, J.F. (Johan), Lam, K.H. (King), Horst, P.H. (Paul) van der, Vakalopoulos, K.A. (Konstantinos), Wu, Z. (Zhouqiao), Kroese, L.F. (Leonard)   +7 more
core   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Development of biodegradable hyper-branched tissue adhesives for the repair of meniscus tears [PDF]

, 2016
Item does not contain fulltextMeniscus tears are one of the most commonly occurring injuries of the knee joint. Current meniscus repair techniques are challenging and do not bring fully satisfactory results.
Grijpma, D.W., van Tienen, T.G., Bochynska, Agnieszka, Hannink, G., Grijpma, D. W., Bochynska, A. I., Buma, P., Van Tienen, T. G., Tienen, T.G. van, Bochynska, A., Grijpma, Dirk W., Hannink, G.J.   +11 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Black phosphorus boosts wet-tissue adhesion of composite patches by enhancing water absorption and mechanical properties

Nature Communications
Wet-tissue adhesives have long been attractive materials for realizing complicated biomedical functions. However, the hydration film on wet tissues can generate a boundary, forming hydrogen bonds with the adhesives that weaken adhesive strength ...
Yuanchi Zhang, Cairong Li, Along Guo, Yipei Yang, Yangyi Nie, Jiaxin Liao, Ben Liu, Yanmei Zhou, Long Li, Zhitong Chen, Wei Zhang, Ling Qin, Yuxiao Lai   +12 more
doaj   +1 more source

Comparison of Arterial Repair through the Suture, Suture with Fibrin or Cyanoacrylate Adhesive in Ex-Vivo Porcine Aortic Segment

Brazilian Journal of Cardiovascular Surgery
Introduction: Tissue adhesives can be used as adjacent to sutures to drop or avoid bleeding in cardiovascular operations. Objective: To verify the efficiency of fibrin and cyanoacrylate adhesive to seal arterial sutures and if the adhesives penetrate ...
Marcus Vinicius H. de Carvalho, Evaldo Marchi, Edmir Américo Lourenço   +2 more
doaj   +1 more source

Tissue adhesives for closure of sugical incisions (Review)

, 2006
Background: Sutures, staples and adhesive tapes are the traditional methods of wound closure, whilst tissue adhesives have entered clinical practice more recently.
Esposito, M., Worthington, H.; id_orcid, Coulthard, P.; id_orcid, Van Waes, O. J F, Van Der Elst, M.   +4 more
core   +1 more source